scholarly journals Hepatoxicity of aqueous extract and fractionated methanol extract of Phytolacca americana by isolated rat liver perfusion system

2010 ◽  
Vol 9 (8) ◽  
pp. 1211-1217
Author(s):  
Karami Mohammad ◽  
Naghshvar Farshad ◽  
Saeidnia Sodabah ◽  
Omrani Nada
Keyword(s):  
Rat Liver ◽  
Aqueous Extract ◽  
Methanol Extract ◽  
Liver Perfusion ◽  
Phytolacca Americana ◽  
Perfusion System ◽  
Isolated Rat Liver ◽  
Rat Liver Perfusion ◽  
Isolated Rat

EFFECTS OF INSULIN AND GLUCAGON ON PRODUCTION OF RENIN SUBSTRATE BY THE ISOLATED RAT LIVER

1980 ◽  
Vol 85 (1) ◽  
pp. 151-153 ◽  
Author(s):  
EIKI MURAKAMI ◽  
KUNIO HIWADA ◽  
TATSUO KOKUBU
Keyword(s):  
Normal Control ◽  
Rat Liver ◽  
Liver Perfusion ◽  
Perfusion System ◽  
Angiotensin I ◽  
Renin Substrate ◽  
Isolated Rat Liver ◽  
Rat Liver Perfusion ◽  
Isolated Rat

SUMMARY An isolated rat liver perfusion system was used to study the effects of insulin and glucagon on renin substrate production. Normal livers synthesized renin substrate at a rate of 28·3 ± 3·8 (s.e.m.) ng angiotensin I equiv./g liver each h (n = 8). The addition of insulin (more than 0·1 i.u.) to the perfusion significantly enhanced the production of renin substrate which was about twofold higher than normal control values (P< 0·001). However, glucagon (20 μg) did not affect the synthesis of renin substrate. These results indicated that insulin promoted the synthesis of renin substrate by the isolated rat liver.

Uptake Characteristics of Oligonucleotides in the Isolated Rat Liver Perfusion System

1996 ◽  
Vol 6 (3) ◽  
pp. 177-183 ◽  
Author(s):  
YOSHINOBU TAKAKURA ◽  
RAM I. MAHATO ◽  
MITSUNOBU YOSHIDA ◽  
TARO KANAMARU ◽  
MITSURU HASHIDA
Keyword(s):  
Rat Liver ◽  
Liver Perfusion ◽  
Perfusion System ◽  
Isolated Rat Liver ◽  
Rat Liver Perfusion ◽  
Isolated Rat

Uridine regulation by the isolated rat liver: perfusion with an artificial oxygen carrier

1982 ◽  
Vol 242 (5) ◽  
pp. R465-R470 ◽  
Author(s):  
A. Monks ◽  
R. L. Cysyk
Keyword(s):  
Rat Liver ◽  
Oxygen Carrier ◽  
Liver Perfusion ◽  
Blood Substitute ◽  
Rat Plasma ◽  
Perfusion Medium ◽  
Artificial Oxygen Carrier ◽  
Isolated Rat Liver ◽  
Rat Liver Perfusion ◽  
Isolated Rat

The isolated rat liver was used to investigate the role of the liver in the regulation of circulating uridine concentrations. A synthetic blood substitute (Fluosol-43) was utilized as an alternative oxygen-carrying perfusion medium to a simplified blood preparation and produced no apparent hepatotoxicity within the perfusion period. The isolated rat liver excreted uridine into a circulating perfusion medium achieving concentrations similar to those found in rat plasma (1.4 +/- 0.6 microM). The mean output of uridine over 2 h was 107 nmol.h-1.g liver-1, but if the perfusate was recirculated the net output of uridine was reduced to 12.7 nmol.h-1.g-1. The rate of depletion of nonphysiological concentrations of circulating uridine was found to be concentration dependent up to 25 microM. At a steady state of circulating uridine, a radioactive uridine spike was cleared with a half-life of 7.4 min and an elimination constant of 0.094 min-1; 30% of the radioactivity appeared in the perfusate as metabolites of uridine within 40 min. Thus the perfused rat liver acts to maintain circulating uridine concentrations similar to those measured in plasma.

The Protective Effects of Antioxidants and Propranolol on Hepatotoxicity of TCDD During Isolated Rat Liver Perfusion

2005 ◽  
Vol 1 (4) ◽  
pp. 336-341 ◽  
Author(s):  
M. Ghazi-Khan ◽  
M. Karami . ◽  
M. Rezayat . ◽  
M. Abdollahi . ◽  
B. Minaie . ◽  
...  
Keyword(s):  
Rat Liver ◽  
Liver Perfusion ◽  
Protective Effects ◽  
Isolated Rat Liver ◽  
Rat Liver Perfusion ◽  
Isolated Rat
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