Enhances Seismic Q-compensation I: Algorithm Formulation and Synthetic Application

Wasiu O. Raji; A. Rietbrock

doi:10.5923/j.fs.20120206.18

Synthesis of allylic alcohol single-chain PGH analogs. A synthetic application of the argon laser

The Journal of Organic Chemistry ◽

10.1021/jo00371a021 ◽

1986 ◽

Vol 51 (21) ◽

pp. 4028-4035 ◽

Cited By ~ 8

Author(s):

R. Marshall Wilson ◽

Karlyn A. Schnapp ◽

Richard K. Merwin ◽

Revathi Ranganthan ◽

David L. Moats ◽

...

Keyword(s):

Argon Laser ◽

Allylic Alcohol ◽

Single Chain ◽

Synthetic Application

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2-Aryl-6-Polyfluoroalkyl-4-Pyrones as Promising RF-Building-Blocks: Synthesis and Application for Construction of Fluorinated Azaheterocycles

Molecules ◽

10.3390/molecules26154415 ◽

2021 ◽

Vol 26 (15) ◽

pp. 4415

Author(s):

Sergey A. Usachev ◽

Diana I. Nigamatova ◽

Daria K. Mysik ◽

Nikita A. Naumov ◽

Dmitrii L. Obydennov ◽

...

Keyword(s):

Direct Synthesis ◽

Building Blocks ◽

Oxidative Cyclization ◽

One Pot ◽

Synthetic Application ◽

General Method

A convenient and general method for the direct synthesis of 2-aryl-6-(trifluoromethyl)-4-pyrones and 2-aryl-5-bromo-6-(trifluoromethyl)-4-pyrones has been developed on the basis of one-pot oxidative cyclization of (E)-6-aryl-1,1,1-trifluorohex-5-ene-2,4-diones via a bromination/dehydrobromination approach. This strategy was also applied for the preparation of 2-phenyl-6-polyfluoroalkyl-4-pyrones and their 5-bromo derivatives. Conditions of chemoselective enediones bromination were found and the key intermediates of the cyclization of bromo-derivatives to 4-pyrones were characterized. Synthetic application of the prepared 4-pyrones has been demonstrated for the construction of biologically important CF3-bearing azaheterocycles, such as pyrazoles, pyridones, and triazoles.

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Base-Free Synthesis and Synthetic Application of Novel 3-(organochalcogenyl)prop-2-yn-1-yl Esters: Promising Anticancer Agents

Synthesis ◽

10.1055/a-1477-6470 ◽

2021 ◽

Author(s):

Fabiane Gritzenco ◽

Jean Carlo Kazmierczak ◽

Thiago Anjos ◽

Adriane Sperança ◽

Maura Luise Bruckchem Peixoto ◽

...

Keyword(s):

Anticancer Agents ◽

Cross Coupling ◽

Coupling Reactions ◽

Chalcogen Bond ◽

Cross Coupling Reactions ◽

Air Atmosphere ◽

Carbon Carbon Bonds ◽

Palladium Catalyzed ◽

Synthetic Application

This manuscript portrays the CuI-catalyzed Csp-chalcogen bond formation through cross-coupling reactions of propynyl esters and diorganyl dichalcogenides by using DMSO as solvent, at room temperature, under base-free and open-to-air atmosphere. Generally, the reactions have proceeded very smoothly, being tolerant to range of substituents present in both substrates, affording the novel 3-(organochalcogenyl)prop-2-yn-1-yl esters in moderate to good yields. Noteworthy, the 3-(butylselanyl)prop-2-yn-1-yl benzoate proved to be useful as synthetic precursor in palladium-catalyzed Suzuki and Sonogashira type cross-coupling reactions by replacing the carbon-chalcogen bond by new carbon-carbon bonds. Moreover, the 3-(phenylselanyl)prop-2-yn-1-yl benzoate has shown promising in vitro activity against glioblastoma cancer cells.

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