Pathological and immunohistochemical evaluations of extra genital transmissible venereal tumour in dogs: a report of two cases

Background: Canine transmissible venereal tumour (CTVT) also known as infectious sarcoma, venereal granuloma, transmissible lymphosarcoma or sticker tumour is usually transmitted through coitus and mainly affects the external genitalia of young sexually matured dogs. Surgery, chemotherapy, radiotherapy and immunotherapy are considered as effective treatment protocols. Therefore, depending upon the availability present study was designed to investigate the efficacy of different surgico-chemotherapeutic protocols for treatment of canine transmissible venereal tumour.Methods: The study was conducted during January 2018 to July 2018 at the Teaching Veterinary Clinical Complex (TVCC) and Department of Veterinary Surgery and Radiology, College of Veterinary Science and A.H., Anjora, Durg (C.G.) on 18 canines of various breed, irrespective of age, sex and divided into three groups consisting 6 animals in each group. Group A was treated with surgical excision of tumour only where as Group B and Group C were treated with surgical excision of tumour followed by administration of Doxorubicin (30mg/m2) BSA and Vincristine sulphate (0.025 mg/kg) intravenously alongwith DNS at 7th and 14th post-operative days respectively. Different physiological and haemato-biochemical parameters (Hb, PCV, TLC, TPC, DLC, serum glucose, TSP, SUN, SC, ALT, AST and ALP) were recorded preoperatively, postoperatively and after chemotherapy at 10th, 30th and 60th days intervals.Result: The present investigation showed transient changes in physiological and haemato-biochemical parameters before, post surgery and post chemotherapeutic management and was within normal range. Histopathological examination revealed confluent sheet of tumour cells arranged in large round oval or polyhedral shaped distributed in tight clusters or cords. Group A showed mild to moderated reoccurrence while Group B showed minimum reoccurrence. Group C showed no reoccurrence. Thus, surgery combined with vincristine therapy is most effective for treating dogs suffering with transmissible venereal tumour.

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Comparative efficacy of surgery, vincristine sulphate and combined therapy of levamisole and Bacille Calmette Guerin vaccine in the treatment of transmissible venereal tumour-infected dogs

Comparative Clinical Pathology ◽

10.1007/s00580-013-1773-x ◽

2013 ◽

Vol 23 (5) ◽

pp. 1263-1267 ◽

Cited By ~ 1

Author(s):

Chinedu Athanasius Eze ◽

Raphael O. C. Kene ◽

Humphrey C. Anyanwu

Keyword(s):

Combined Therapy ◽

Comparative Efficacy ◽

Bacille Calmette Guerin ◽

Vincristine Sulphate ◽

Transmissible Venereal Tumour

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Evaluation of a genetic assay for canine transmissible venereal tumour diagnosis in Brazil

Veterinary and Comparative Oncology ◽

10.1111/vco.12205 ◽

2016 ◽

Vol 15 (2) ◽

pp. 615-618 ◽

Cited By ~ 3

Author(s):

K. F. Castro ◽

A. Strakova ◽

M. Tinucci-Costa ◽

E. P. Murchison

Keyword(s):

Tumour Diagnosis ◽

Canine Transmissible Venereal Tumour ◽

Transmissible Venereal Tumour ◽

Genetic Assay

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Successful Management of Metastatic Transmissible Venereal Tumour to Skin of Mammary Region

Reproduction in Domestic Animals ◽

10.1111/rda.12105 ◽

2012 ◽

Vol 47 ◽

pp. 366-369 ◽

Cited By ~ 1

Author(s):

EE Varughese ◽

VK Singla ◽

U Ratnakaran ◽

VK Gandotra

Keyword(s):

Successful Management ◽

Transmissible Venereal Tumour

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Primary transmissible venereal tumour in the nasal cavity of a dog

Veterinary Record ◽

10.1136/vr.136.9.222 ◽

1995 ◽

Vol 136 (9) ◽

pp. 222-223 ◽

Cited By ~ 12

Author(s):

P. Ginel ◽

J. Molleda ◽

M. Novales ◽

E. Martin ◽

J. Margarito ◽

...

Keyword(s):

Nasal Cavity ◽

Transmissible Venereal Tumour

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Nasal Transmissible Venereal Tumor In A Jack Russel Terrier Bitch

Acta veterinaria ◽

10.1515/acve-2015-0012 ◽

2015 ◽

Vol 65 (1) ◽

pp. 143-148 ◽

Cited By ~ 1

Author(s):

FEGHIU Adrian ◽

CRÎNGANU Dan ◽

DUMITRESCU Florin ◽

PASCAL Manuela ◽

VASILESCU Florina ◽

...

Keyword(s):

Monoclonal Antibody ◽

Veterinary Medicine ◽

Nasal Cavity ◽

Tumor Tissue ◽

Left Nasal Cavity ◽

Vincristine Sulphate ◽

Positive Immunoreactivity ◽

Canine Transmissible Venereal Tumour ◽

Transmissible Venereal Tumour ◽

Primary Form

Abstract A two-year old Jack Russell Terrier female with left-sided epistaxis was brought to the Clinic of the Bucharest Faculty of Veterinary Medicine. Endoscopy of the left nasal cavity revealed a cauliflower-like mass. Cytological and histopathological features were specific to canine transmissible venereal tumour (CTVT). Tumor tissue showed positive immunoreactivity to anti-vimentin monoclonal antibody (90%) and Ki67 (35%) and samples were negative for anti-cytokeratin monoclonal antibody. Chemotherapy with vincristine sulphate at a dose of 0.025 mg/kg i.v./week for 6 administrations was successful. This paper presents a primary form of nasal CTVT in a Jack Russell Terrier female.

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