scholarly journals Author response: Synaptic up-scaling preserves motor circuit output after chronic, natural inactivity

2017 ◽  
Author(s):  
Joseph M Santin ◽  
Mauricio Vallejo ◽  
Lynn K Hartzler
Keyword(s):  
Author Response ◽  
Motor Circuit ◽  
Circuit Output ◽  
Up Scaling

scholarly journals Synaptic up-scaling preserves motor circuit output after chronic, natural inactivity

eLife ◽  
2017 ◽  
Vol 6 ◽  
Author(s):  
Joseph M Santin ◽  
Mauricio Vallejo ◽  
Lynn K Hartzler
Keyword(s):  
Adult Animal ◽  
Homeostatic Plasticity ◽  
Neural Systems ◽  
Normal Brain ◽  
Motor Circuit ◽  
Brain Functions ◽  
Respiratory Network ◽  
Classic Form ◽  
Circuit Output ◽  
Up Scaling

Neural systems use homeostatic plasticity to maintain normal brain functions and to prevent abnormal activity. Surprisingly, homeostatic mechanisms that regulate circuit output have mainly been demonstrated during artificial and/or pathological perturbations. Natural, physiological scenarios that activate these stabilizing mechanisms in neural networks of mature animals remain elusive. To establish the extent to which a naturally inactive circuit engages mechanisms of homeostatic plasticity, we utilized the respiratory motor circuit in bullfrogs that normally remains inactive for several months during the winter. We found that inactive respiratory motoneurons exhibit a classic form of homeostatic plasticity, up-scaling of AMPA-glutamate receptors. Up-scaling increased the synaptic strength of respiratory motoneurons and acted to boost motor amplitude from the respiratory network following months of inactivity. Our results show that synaptic scaling sustains strength of the respiratory motor output following months of inactivity, thereby supporting a major neuroscience hypothesis in a normal context for an adult animal.

scholarly journals Author response: Striatal fast-spiking interneurons selectively modulate circuit output and are required for habitual behavior

2017 ◽  
Author(s):  
Justin K O'Hare ◽  
Haofang Li ◽  
Namsoo Kim ◽  
Erin Gaidis ◽  
Kristen Ade ◽  
...  
Keyword(s):  
Author Response ◽  
Fast Spiking ◽  
Habitual Behavior ◽  
Circuit Output

scholarly journals Modulation of Circuit Feedback Specifies Motor Circuit Output

2012 ◽  
Vol 32 (27) ◽  
pp. 9182-9193 ◽  
Author(s):  
D. M. Blitz ◽  
M. P. Nusbaum
Keyword(s):  
Motor Circuit ◽  
Circuit Output

scholarly journals Author response: Neuronal connectome of a sensory-motor circuit for visual navigation

2014 ◽  
Author(s):  
Nadine Randel ◽  
Albina Asadulina ◽  
Luis A Bezares-Calderón ◽  
Csaba Verasztó ◽  
Elizabeth A Williams ◽  
...  
Keyword(s):  
Visual Navigation ◽  
Author Response ◽  
Motor Circuit ◽  
Sensory Motor

scholarly journals Parallel Regulation of a Modulator-Activated Current via Distinct Dynamics Underlies Comodulation of Motor Circuit Output

2009 ◽  
Vol 29 (39) ◽  
pp. 12355-12367 ◽  
Author(s):  
N. D. DeLong ◽  
M. S. Kirby ◽  
D. M. Blitz ◽  
M. P. Nusbaum
Keyword(s):  
Motor Circuit ◽  
Circuit Output

Author response for "Location and arrangement of campaniform sensilla in Drosophila melanogaster"

2020 ◽  
Author(s):  
Gesa F. Dinges ◽  
Alexander S. Chockley ◽  
Till Bockemühl ◽  
Kei Ito ◽  
Alexander Blanke ◽  
...  
Keyword(s):  
Drosophila Melanogaster ◽  
Author Response ◽  
Campaniform Sensilla
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