scholarly journals Author response: Striatal fast-spiking interneurons selectively modulate circuit output and are required for habitual behavior

2017 ◽  
Author(s):  
Justin K O'Hare ◽  
Haofang Li ◽  
Namsoo Kim ◽  
Erin Gaidis ◽  
Kristen Ade ◽  
...  
Keyword(s):  
Author Response ◽  
Fast Spiking ◽  
Habitual Behavior ◽  
Circuit Output

scholarly journals Striatal fast-spiking interneurons selectively modulate circuit output and are required for habitual behavior

eLife ◽  
2017 ◽  
Vol 6 ◽  
Author(s):  
Justin K O'Hare ◽  
Haofang Li ◽  
Namsoo Kim ◽  
Erin Gaidis ◽  
Kristen Ade ◽  
...  
Keyword(s):  
Behavioral Adaptation ◽  
Single Class ◽  
Gamma Frequency ◽  
Dependent Behavior ◽  
Selective Modulation ◽  
Lever Pressing ◽  
Fast Spiking ◽  
Habitual Behavior ◽  
Circuit Output

Habit formation is a behavioral adaptation that automates routine actions. Habitual behavior correlates with broad reconfigurations of dorsolateral striatal (DLS) circuit properties that increase gain and shift pathway timing. The mechanism(s) for these circuit adaptations are unknown and could be responsible for habitual behavior. Here we find that a single class of interneuron, fast-spiking interneurons (FSIs), modulates all of these habit-predictive properties. Consistent with a role in habits, FSIs are more excitable in habitual mice compared to goal-directed and acute chemogenetic inhibition of FSIs in DLS prevents the expression of habitual lever pressing. In vivo recordings further reveal a previously unappreciated selective modulation of SPNs based on their firing patterns; FSIs inhibit most SPNs but paradoxically promote the activity of a subset displaying high fractions of gamma-frequency spiking. These results establish a microcircuit mechanism for habits and provide a new example of how interneurons mediate experience-dependent behavior.

scholarly journals Author response: Impaired fast-spiking interneuron function in a genetic mouse model of depression

2015 ◽  
Author(s):  
Jonas-Frederic Sauer ◽  
Michael Strüber ◽  
Marlene Bartos
Keyword(s):  
Mouse Model ◽  
Author Response ◽  
Genetic Mouse Model ◽  
Fast Spiking

scholarly journals Author response: Synaptic up-scaling preserves motor circuit output after chronic, natural inactivity

2017 ◽  
Author(s):  
Joseph M Santin ◽  
Mauricio Vallejo ◽  
Lynn K Hartzler
Keyword(s):  
Author Response ◽  
Motor Circuit ◽  
Circuit Output ◽  
Up Scaling

scholarly journals Repeated cocaine exposure increases fast-spiking interneuron excitability in the rat medial prefrontal cortex

2013 ◽  
Vol 109 (11) ◽  
pp. 2781-2792 ◽  
Author(s):  
Emilie Campanac ◽  
Dax A. Hoffman
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Pyramidal Neurons ◽  
Input Resistance ◽  
Compensatory Mechanism ◽  
Cocaine Exposure ◽  
Membrane Excitability ◽  
Chronic Cocaine ◽  
Fast Spiking ◽  
Circuit Output

The medial prefrontal cortex plays a key role in cocaine addiction. However, how chronic cocaine exposure affects cortical networks remains unclear. Most studies have focused on layer 5 pyramidal neurons (the circuit output), while the response of local GABAergic interneurons to cocaine remains poorly understood. Here, we recorded from fast-spiking interneurons (FS-IN) after repeated cocaine exposure and found altered membrane excitability. After cocaine withdrawal, FS-IN showed an increase in the number of spikes evoked by positive current injection, increased input resistance, and decreased hyperpolarization-activated current. We also observed a reduction in miniature excitatory postsynaptic currents, whereas miniature inhibitory postsynaptic current activity was unaffected. We show that, in animals with cocaine history, dopamine receptor D2 activation is less effective in increasing FS-IN intrinsic excitability. Interestingly, these alterations are only observed 1 wk or more after the last cocaine exposure. This suggests that the dampening of D2-receptor-mediated response may be a compensatory mechanism to rein down the excitability of FS-IN.

scholarly journals Author response: Serotonin enhances excitability and gamma frequency temporal integration in mouse prefrontal fast-spiking interneurons

2017 ◽  
Author(s):  
Jegath C Athilingam ◽  
Roy Ben-Shalom ◽  
Caroline M Keeshen ◽  
Vikaas S Sohal ◽  
Kevin J Bender
Keyword(s):  
Temporal Integration ◽  
Author Response ◽  
Gamma Frequency ◽  
Fast Spiking

scholarly journals Striatal fast-spiking interneurons drive habitual behavior

2017 ◽  
Author(s):  
Justin K. O’Hare ◽  
Haofang Li ◽  
Namsoo Kim ◽  
Erin Gaidis ◽  
Kristen K. Ade ◽  
...  
Keyword(s):  
Habit Formation ◽  
Behavioral Adaptation ◽  
Single Class ◽  
Gamma Frequency ◽  
Dependent Behavior ◽  
Selective Modulation ◽  
Lever Pressing ◽  
Fast Spiking ◽  
Habitual Behavior

AbstractHabit formation is a behavioral adaptation that automates routine actions. Habitual behavior correlates with broad reconfigurations of dorsolateral striatal (DLS) circuit properties that increase gain and shift pathway timing. The mechanism(s) for these circuit adaptations are unknown and could be responsible for habitual behavior. Here we find that a single class of interneuron, fast-spiking interneurons (FSIs), modulates all of these habit-predictive properties. Consistent with a role in habits, FSIs are more excitable in habitual mice compared to goal-directed and acute chemogenetic inhibition of FSIs in DLS prevents the expression of habitual lever pressing. In vivo recordings further reveal a previously unappreciated selective modulation of SPNs based on their firing patterns; FSIs inhibit most SPNs but paradoxically promote the activity of a subset displaying high fractions of gamma-frequency spiking. These results establish a microcircuit mechanism for habits and provide a new example of how interneurons mediate experience-dependent behavior.

scholarly journals Author response: Functional effects of distinct innervation styles of pyramidal cells by fast spiking cortical interneurons

2015 ◽  
Author(s):  
Yoshiyuki Kubota ◽  
Satoru Kondo ◽  
Masaki Nomura ◽  
Sayuri Hatada ◽  
Noboru Yamaguchi ◽  
...  
Keyword(s):  
Pyramidal Cells ◽  
Author Response ◽  
Cortical Interneurons ◽  
Fast Spiking
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