scholarly journals Author response: M2 cortex-dorsolateral striatum stimulation reverses motor symptoms and synaptic deficits in Huntington’s disease

2020 ◽  
Author(s):  
Sara Fernández-García ◽  
Sara Conde-Berriozabal ◽  
Esther García-García ◽  
Clara Gort-Paniello ◽  
David Bernal-Casas ◽  
...  
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Author Response ◽  
Motor Symptoms ◽  
Dorsolateral Striatum

scholarly journals M2 Cortex-Dorsolateral striatum stimulation reverses motor symptoms and synaptic deficits in Huntington’s Disease

2020 ◽  
Author(s):  
Sara Fernández-García ◽  
Sara Conde-Berriozabal ◽  
Esther García-García ◽  
Clara Gort-Paniello ◽  
David Bernal-Casas ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Motor Behavior ◽  
Glutamate Release ◽  
Motor Symptoms ◽  
Striatal Neurons ◽  
Dorsolateral Striatum ◽  
Electrophysiological Responses

AbstractHuntington’s disease (HD) is a neurological disorder characterized by motor disturbances. HD pathology is most prominent in the striatum, the central hub of basal ganglia. The cortex is the main striatal afference and progressive cortico-striatal disconnection characterizes HD. We mapped cortico-striatal dysfunction in HD mice to ultimately modulate the activity of selected cortico-striatal circuits to ameliorate motor symptoms and recover synaptic plasticity. Multimodal MRI in vivo suggested prominent functional network deficits in fronto-striatal compared to motor-striatal pathways, which were accompanied by reduced glutamate levels in the striatum of HD mice. Moreover, optogenetically-stimulated glutamate release from fronto-striatal terminals was reduced in HD mice and electrophysiological responses in striatal neurons were blunted. Remarkably, repeated M2 Cortex-dorsolateral striatum optogenetic stimulation normalized motor behavior in HD mice and evoked a sustained increase of synaptic plasticity. Overall, these results reveal that the selective stimulation of fronto-striatal pathways can become an effective therapeutic strategy in HD.

scholarly journals M2 cortex-dorsolateral striatum stimulation reverses motor symptoms and synaptic deficits in Huntington’s disease

eLife ◽  
2020 ◽  
Vol 9 ◽  
Author(s):  
Sara Fernández-García ◽  
Sara Conde-Berriozabal ◽  
Esther García-García ◽  
Clara Gort-Paniello ◽  
David Bernal-Casas ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Motor Behavior ◽  
Glutamate Release ◽  
Motor Symptoms ◽  
Striatal Neurons ◽  
Dorsolateral Striatum ◽  
Electrophysiological Responses

Huntington’s disease (HD) is a neurological disorder characterized by motor disturbances. HD pathology is most prominent in the striatum, the central hub of the basal ganglia. The cerebral cortex is the main striatal afferent, and progressive cortico-striatal disconnection characterizes HD. We mapped striatal network dysfunction in HD mice to ultimately modulate the activity of a specific cortico-striatal circuit to ameliorate motor symptoms and recover synaptic plasticity. Multimodal MRI in vivo indicates cortico-striatal and thalamo-striatal functional network deficits and reduced glutamate/glutamine ratio in the striatum of HD mice. Moreover, optogenetically-induced glutamate release from M2 cortex terminals in the dorsolateral striatum (DLS) was undetectable in HD mice and striatal neurons show blunted electrophysiological responses. Remarkably, repeated M2-DLS optogenetic stimulation normalized motor behavior in HD mice and evoked a sustained increase of synaptic plasticity. Overall, these results reveal that selective stimulation of the M2-DLS pathway can become an effective therapeutic strategy in HD.

66. Effects of cranio-spinal tDCS in the treatment of cognitive and motor symptoms in early Huntington’s Disease

2016 ◽  
Vol 127 (12) ◽  
pp. e339
Author(s):  
L. Parenti ◽  
D. Barloscio ◽  
M. Bartolotta ◽  
A. Di Rollo ◽  
F. Sartucci ◽  
...  
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Motor Symptoms

Author response for "The relationship between lifestyle and serum neurofilament light protein in Huntington’s disease"

2020 ◽  
Author(s):  
Travis Cruickshank ◽  
Danielle Bartlett ◽  
Andrew Govus ◽  
Anthony Hannan ◽  
Wei‐Peng Teo ◽  
...  
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Author Response ◽  
Neurofilament Light ◽  
The Relationship

scholarly journals Time-Restricted Feeding Improves Circadian Dysfunction as well as Motor Symptoms in the Q175 Mouse Model of Huntington’s Disease

eNeuro ◽  
2018 ◽  
Vol 5 (1) ◽  
pp. ENEURO.0431-17.2017 ◽  
Author(s):  
Huei-Bin Wang ◽  
Dawn H. Loh ◽  
Daniel S. Whittaker ◽  
Tamara Cutler ◽  
David Howland ◽  
...  
Keyword(s):  
Mouse Model ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Motor Symptoms ◽  
Restricted Feeding ◽  
Circadian Dysfunction

The impact of an intense religious experience on motor symptoms in Huntington's disease

2008 ◽  
Vol 24 (3) ◽  
pp. 473-474 ◽  
Author(s):  
Jose Luis López-Sendón Moreno ◽  
Justo Garcia de Yebenes
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Religious Experience ◽  
Motor Symptoms ◽  
The Impact

Author response for "Longitudinal atrophy characterization of cortical and subcortical gray matter in Huntington's disease patients"

2019 ◽  
Author(s):  
Gabriel Ramirez‐Garcia ◽  
Víctor Galvez ◽  
Rosalinda Diaz ◽  
Leo Bayliss ◽  
Juan Fernandez‐Ruiz ◽  
...  
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Gray Matter ◽  
Author Response

F46 Relationship between distinct motor symptoms and apathy in huntington’s disease: clues to mechanism

2018 ◽  
Author(s):  
Akshay Nair ◽  
N Ahmad Aziz ◽  
Robb Rutledge ◽  
Geraint Rees ◽  
Sarah J Tabrizi
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Motor Symptoms
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