scholarly journals Immunization with a Synthetic Peptide Vaccine Fails to Protect Mule Deer (Odocoileus hemionus) from Chronic Wasting Disease

2013 ◽  
Vol 49 (3) ◽  
pp. 694-698 ◽  
Author(s):  
John L. Pilon ◽  
Jack C. Rhyan ◽  
Lisa L. Wolfe ◽  
Tracy R. Davis ◽  
Matt P. McCollum ◽  
...  
Keyword(s):  
Synthetic Peptide ◽  
Chronic Wasting Disease ◽  
Mule Deer ◽  
Peptide Vaccine ◽  
Odocoileus Hemionus ◽  
Wasting Disease ◽  
Synthetic Peptide Vaccine

Topographic distribution of scrapie amyloid-immunoreactive plaques in chronic wasting disease in captive mule deer (Odocoileus hemionus hemionus)

1991 ◽  
Vol 81 (5) ◽  
pp. 475-478 ◽  
Author(s):  
D. C. Guiroy ◽  
E. S. Williams ◽  
R. Yanagihara ◽  
D. C. Gajdusek
Keyword(s):  
Chronic Wasting Disease ◽  
Mule Deer ◽  
Odocoileus Hemionus ◽  
Wasting Disease ◽  
Topographic Distribution

scholarly journals Impacts of chronic wasting disease on a low density mule deer (Odocoileus hemionus) population in the San Andres Mountains, Chihuahuan Desert, New Mexico

2019 ◽  
Vol 35 ◽  
pp. 1-11
Author(s):  
Louis C. Bender ◽  
Cristina L. Rodden ◽  
Pat Mathis ◽  
Mara E. Weisenberger ◽  
Octavio C. Rosas Rosas ◽  
...  
Keyword(s):  
New Mexico ◽  
Chronic Wasting Disease ◽  
Chihuahuan Desert ◽  
Mule Deer ◽  
Odocoileus Hemionus ◽  
Low Density ◽  
Wasting Disease ◽  
San Andres

scholarly journals Low frequency of PrP genotype 225SF among free-ranging mule deer (Odocoileus hemionus) with chronic wasting disease

2005 ◽  
Vol 86 (8) ◽  
pp. 2127-2134 ◽  
Author(s):  
Jean E. Jewell ◽  
Mary M. Conner ◽  
Lisa L. Wolfe ◽  
Michael W. Miller ◽  
Elizabeth S. Williams
Keyword(s):  
Dna Sequences ◽  
Chronic Wasting Disease ◽  
Mule Deer ◽  
Low Frequency ◽  
Odocoileus Hemionus ◽  
Infection Status ◽  
Wasting Disease ◽  
Incubation Periods ◽  
Free Ranging ◽  
Prp Gene

The prion protein (PrP) gene was characterized in 1482 free-ranging mule deer (Odocoileus hemionus) from Wyoming and Colorado. Using DNA sequences from 363 deer, dimorphisms at codons 20 (aspartate/glycine) and 225 [serine (S)/phenylalanine (F)] were found; silent changes occurred at codons 131 (tyrosine) and 247 (isoleucine). The remaining samples were surveyed for codon 225 genotype and all were characterized for chronic wasting disease (CWD) infection status. A total of 112 deer with the genotype 225SF or FF were found, of which one was CWD-positive; 1370 were 225SS, with 289 positive for CWD. Among CWD-negative deer, the frequency of 225SF/FF genotypes was 9·3 % but among CWD-positive deer it was only 0·3 %. For all samples combined, CWD status was not independent of codon 225 genotype (P<0·0001). The odds that a deer of the 225SS genotype was CWD-infected were 30 times greater (95 % confidence intervals=4–213) than for a 225SF deer. The proportion of 225SF animals in sampled subpopulations varied from 0 to 18 %; the CWD prevalence varied from 0 to 25 %. However, no relationship was observed between genotype frequency and CWD prevalence in different areas. The PrP sequences of experimentally infected mule deer were analysed from pre-existing projects and 10 animals were found with 225SF genotypes, all of which were positive for CWD. Data available from some of these animals suggest that the 225SF genotype could be associated with longer incubation periods in CWD infection compared with the 225SS genotype.

scholarly journals Oral transmission and early lymphoid tropism of chronic wasting disease PrPres in mule deer fawns (Odocoileus hemionus )

1999 ◽  
Vol 80 (10) ◽  
pp. 2757-2764 ◽  
Author(s):  
Christina J. Sigurdson ◽  
Elizabeth S. Williams ◽  
Michael W. Miller ◽  
Terry R. Spraker ◽  
Katherine I. O’Rourke ◽  
...  
Keyword(s):  
Lymph Node ◽  
Alimentary Tract ◽  
Chronic Wasting Disease ◽  
Mule Deer ◽  
Odocoileus Hemionus ◽  
Oral Exposure ◽  
Spongiform Encephalopathy ◽  
Lymphoid Tissues ◽  
Acid Proteinase ◽  
Wasting Disease

Mule deer fawns (Odocoileus hemionus) were inoculated orally with a brain homogenate prepared from mule deer with naturally occurring chronic wasting disease (CWD), a prion-induced transmissible spongiform encephalopathy. Fawns were necropsied and examined for PrP res, the abnormal prion protein isoform, at 10, 42, 53, 77, 78 and 80 days post-inoculation (p.i.) using an immunohistochemistry assay modified to enhance sensitivity. PrPres was detected in alimentary-tract-associated lymphoid tissues (one or more of the following: retropharyngeal lymph node, tonsil, Peyer’s patch and ileocaecal lymph node) as early as 42 days p.i. and in all fawns examined thereafter (53 to 80 days p.i.). No PrPres staining was detected in lymphoid tissue of three control fawns receiving a control brain inoculum, nor was PrPres detectable in neural tissue of any fawn. PrPres-specific staining was markedly enhanced by sequential tissue treatment with formic acid, proteinase K and hydrated autoclaving prior to immunohistochemical staining with monoclonal antibody F89/160.1.5. These results indicate that CWD PrP res can be detected in lymphoid tissues draining the alimentary tract within a few weeks after oral exposure to infectious prions and may reflect the initial pathway of CWD infection in deer. The rapid infection of deer fawns following exposure by the most plausible natural route is consistent with the efficient horizontal transmission of CWD in nature and enables accelerated studies of transmission and pathogenesis in the native species.

scholarly journals Validation of Monoclonal Antibody F99/97.6.1 for Immunohistochemical Staining of Brain and Tonsil in Mule Deer (Odocoileus Hemionus) with Chronic Wasting Disease

2002 ◽  
Vol 14 (1) ◽  
pp. 3-7 ◽  
Author(s):  
T. R. Spraker ◽  
K. I. O'Rourke ◽  
A. Balachandran ◽  
R. R. Zink ◽  
B. A. Cummings ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Immunohistochemical Staining ◽  
Chronic Wasting Disease ◽  
Mule Deer ◽  
Odocoileus Hemionus ◽  
Wasting Disease

Neuropathology of Chronic Wasting Disease of Mule Deer (Odocoileus hemionus) and Elk (Cervus elaphus nelsoni)

1993 ◽  
Vol 30 (1) ◽  
pp. 36-45 ◽  
Author(s):  
E. S. Williams ◽  
S. Young
Keyword(s):  
Bovine Spongiform Encephalopathy ◽  
Cervus Elaphus ◽  
Chronic Wasting Disease ◽  
Neuronal Degeneration ◽  
Mule Deer ◽  
Amyloid Plaques ◽  
Odocoileus Hemionus ◽  
Spongiform Encephalopathy ◽  
Wasting Disease ◽  
Cervus Elaphus Nelsoni

The pathology of the central nervous system of nine mule deer ( Odocoileus hemionus) and six elk ( Cervus elaphus nelsoni) with chronic wasting disease, a spongiform encephalopathy of mule deer and elk, was studied by light microscopy. Lesions were similar in both species and were characterized by spongiform transformation of gray matter, intracytoplasmic vacuolation of neurons, neuronal degeneration and loss, astrocytic hypertrophy and hyperplasia, occurrence of amyloid plaques, and absence of significant inflammatory response. Distribution and severity of lesions were evaluated at 57 locations; there were only minor differences between deer and elk. Consistent, severe lesions occurred in olfactory tubercle and cortex, hypothalamus, and the parasympathetic vagal nucleus of deer, and sections examined from these regions would be sufficient to establish a diagnosis of chronic wasting disease. Lesions were milder in these locations in elk but were sufficiently apparent to be of diagnostic value. Other differences included increased severity of lesions in some thalamic nuclei in elk in contrast to deer, the occurrence of amyloid plaques demonstrable by hematoxylin and eosin and histochemical stains in deer in contrast to elk, and the presence of mild white matter lesions in elk but not in deer. Lesions of chronic wasting disease were qualitatively comparable to those of scrapie, bovine spongiform encephalopathy, transmissible mink encephalopathy, and the human spongiform encephalopathies. Topographic distribution and lesion severity of chronic wasting disease were most similar to those of scrapie and bovine spongiform encephalopathy. Duration of clinical disease did not significantly influence lesion distribution or severity in either species.

scholarly journals EVALUATION OF A TEST AND CULL STRATEGY FOR REDUCING PREVALENCE OF CHRONIC WASTING DISEASE IN MULE DEER (ODOCOILEUS HEMIONUS)

2018 ◽  
Vol 54 (3) ◽  
pp. 511 ◽  
Author(s):  
Lisa L. Wolfe ◽  
Mary Kay Watry ◽  
Michael A. Sirochman ◽  
Tracey M. Sirochman ◽  
Michael W. Miller
Keyword(s):  
Chronic Wasting Disease ◽  
Mule Deer ◽  
Odocoileus Hemionus ◽  
Wasting Disease

Failure of Fallow Deer (Dama dama) to Develop Chronic Wasting Disease When Exposed to a Contaminated Environment and Infected Mule Deer (Odocoileus hemionus)

2011 ◽  
Vol 47 (3) ◽  
pp. 739-744 ◽  
Author(s):  
Jack C. Rhyan ◽  
Michael W. Miller ◽  
Terry R. Spraker ◽  
Matt McCollum ◽  
Pauline Nol ◽  
...  
Keyword(s):  
Chronic Wasting Disease ◽  
Mule Deer ◽  
Odocoileus Hemionus ◽  
Fallow Deer ◽  
Dama Dama ◽  
Wasting Disease
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