scholarly journals Induced Pluripotent Stem Cells: Next Generation Stem Cells to Clinical Applications

2015 ◽  
Vol 35 (4) ◽  
pp. 190 ◽  
Author(s):  
Jihyun Cha ◽  
Sunhoo Park ◽  
Seung Bum Lee
Keyword(s):  
Stem Cells ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Clinical Applications ◽  
Next Generation ◽  
Induced Pluripotent

Clinical Applications of Induced Pluripotent Stem Cells – Stato Attuale

2018 ◽  
pp. 127-149 ◽  
Author(s):  
Chavali Kavyasudha ◽  
Dannie Macrin ◽  
K. N. ArulJothi ◽  
Joel P. Joseph ◽  
M. K. Harishankar ◽  
...  
Keyword(s):  
Stem Cells ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Clinical Applications ◽  
Induced Pluripotent

scholarly journals Identification of a familial cleidocranial dysplasia with a novel RUNX2 mutation and establishment of patient-derived induced pluripotent stem cells

Odontology ◽  
2021 ◽  
Author(s):  
Atsuko Hamada ◽  
Hanae Mukasa ◽  
Yuki Taguchi ◽  
Eri Akagi ◽  
Fumitaka Obayashi ◽  
...  
Keyword(s):  
Stem Cells ◽  
Next Generation Sequencing ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Hereditary Diseases ◽  
Cleidocranial Dysplasia ◽  
Next Generation ◽  
Human Ipscs ◽  
Induced Pluripotent ◽  
Generation Sequencing

AbstractCleidocranial dysplasia (CCD) is an autosomal dominant hereditary disease associated with the gene RUNX2. Disease-specific induced pluripotent stem cells (iPSCs) have emerged as a useful resource to further study human hereditary diseases such as CCD. In this study, we identified a novel CCD-specific RUNX2 mutation and established iPSCs with this mutation. Biopsies were obtained from familial CCD patients and mutation analyses were performed through Sanger sequencing and next generation sequencing. CCD-specific human iPSCs (CCD-hiPSCs) were established and maintained under completely defined serum, feeder, and integration-free condition using a non-integrating replication-defective Sendai virus vector. We identified the novel mutation RUNX2_c.371C>G and successfully established CCD-hiPSCs. The CCD-hiPSCs inherited the same mutation, possessed pluripotency, and showed the ability to differentiate the three germ layers. We concluded that RUNX2_c.371C>G was likely pathogenic because our results, derived from next generation sequencing, are supported by actual clinical evidence, familial tracing, and genetic data. Thus, we concluded that hiPSCs with a novel CCD-specific RUNX2 mutation are viable as a resource for future studies on CCD.

scholarly journals Human induced pluripotent stem cells—from mechanisms to clinical applications

2012 ◽  
Vol 90 (7) ◽  
pp. 735-745 ◽  
Author(s):  
Katharina Drews ◽  
Justyna Jozefczuk ◽  
Alessandro Prigione ◽  
James Adjaye
Keyword(s):  
Stem Cells ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Clinical Applications ◽  
Induced Pluripotent

scholarly journals Induced pluripotent stem cells as a next-generation biomedical interface

2011 ◽  
Vol 91 (7) ◽  
pp. 972-977 ◽  
Author(s):  
Katherine E Hankowski ◽  
Takashi Hamazaki ◽  
Akihiro Umezawa ◽  
Naohiro Terada
Keyword(s):  
Stem Cells ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Next Generation ◽  
Induced Pluripotent
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