Gastrointestinal Stromal Tumor and Ki-67 as a Prognostic Indicator

Abstract Gastrointestinal stromal tumor is a rare neoplasm affecting gastrointestinal tract. Duodenal gastrointestinal stromal tumor originating from the fourth segment is considered an extremely rare disease. Surgical challenges arise when managing locally recurrent hemorrhagic duodenal gastrointestinal stromal tumor. A 58-year-old male presented with melena for the last 10 days. Thirty months previously, he had segmental resection of the fourth duodenal portion due to hemorrhagic gastrointestinal stromal tumor. No adjuvant imatinib therapy was administered (low risk for recurrence). The latest investigations showed actively bleeding tumor in the distal third portion of the duodenum, indicating a locally recurrent gastrointestinal stromal tumor. Uneventful emergent limited resection was performed. To the best of our knowledge, this is the first case report describing locally recurrent gastrointestinal stromal tumor in the distal duodenal portion. We will explain the therapeutic challenges and risk stratification and discuss gastrointestinal bleeding as a prognostic indicator for gastrointestinal stromal tumor recurrence.

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Analysis of the amount of tissue sample necessary for mitotic count and Ki-67 index in gastrointestinal stromal tumor sampling

Oncology Reports ◽

10.3892/or.2014.3608 ◽

2014 ◽

Vol 33 (1) ◽

pp. 215-222 ◽

Cited By ~ 4

Author(s):

HIDEKI KOBARA ◽

HIROHITO MORI ◽

KAZI RAFIQ ◽

SHINTARO FUJIHARA ◽

NORIKO NISHIYAMA ◽

...

Keyword(s):

Gastrointestinal Stromal Tumor ◽

Tissue Sample ◽

Mitotic Count ◽

Stromal Tumor ◽

Ki 67 ◽

Tumor Sampling

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Intramural gastric hematoma imitating a gastrointestinal stromal tumor – case report and literature review

Polish Journal of Surgery ◽

10.5604/01.3001.0009.9159 ◽

2017 ◽

Vol 89 (2) ◽

pp. 62-65 ◽

Cited By ~ 1

Author(s):

Arkadiusz Spychała ◽

Piotr Nowaczyk ◽

Aleksandra Budnicka ◽

Ewa Antoniewicz ◽

Dawid Murawa

Keyword(s):

Case Report ◽

Gastrointestinal Stromal Tumor ◽

Ct Scan ◽

Histopathological Examination ◽

Posterior Wall ◽

Stromal Tumor ◽

Abdominal Ct ◽

Ki 67 ◽

Abdominal Ct Scan

The article presents a case report of a patient with an intramural gastric hematoma. Diagnostic examinations were suggestive of a suspected gastrointestinal stromal tumor Normal image was observed in gastroscopic examination while abdominal CT scan revealed a nodular lesion along the greater curvature of the stomach extending from the posterior wall and adjoining the pancreas and the spleen. The patient was qualified for surgical treatment. Laparotomy was performed followed by total gastric resection and Roux-en-Y reconstruction of the gastrointestinal tract. Post-operative histopathological examination revealed the presence of an extensive hematoma penetrating the perigastric fat tissue along with numerous hemosiderinophages and segmental indicators of formation of inflammatory granulation tissue suggestive of a chronic nature of the lesion. Immunohistochemical GIST assays (CD117, DOG-1, CD34, CD31, SMA, S-100, CKAE1/AE3, Ki-67) were negative. No complications were observed in the post-operative course. Patient is subject to continued follow-up and observation. Follow-up gastroscopy and abdominal CT scan performed 6 months after the surgery revealed an unremarkable image.

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CD133 and Ki-67 expression is associated with gastrointestinal stromal tumor prognosis

Oncology Letters ◽

10.3892/ol.2013.1564 ◽

2013 ◽

Vol 6 (5) ◽

pp. 1289-1294 ◽

Cited By ~ 14

Author(s):

CANRONG LU ◽

LICHENG LIU ◽

XIN WU ◽

WENTONG XU

Keyword(s):

Gastrointestinal Stromal Tumor ◽

Stromal Tumor ◽

Ki 67 ◽

Tumor Prognosis

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Mutations in ALK and TSC1 in a gastrointestinal stromal tumor: a case report

BMC Surgery ◽

10.1186/s12893-021-01208-0 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Qingzhi Song ◽

Guan Li ◽

Zhuofei Li ◽

Sheng Ao ◽

Jianing Hou ◽

...

Keyword(s):

Gastrointestinal Stromal Tumor ◽

Gastrointestinal Stromal Tumors ◽

Gene Mutations ◽

Genetic Mutation ◽

Stromal Tumor ◽

Biological Behavior ◽

Preoperative Imaging ◽

Missense Mutations ◽

Ki 67 ◽

Stromal Tumors

Abstract Background Gastrointestinal stromal tumors rarely occur in children, but when they do, their biological behavior and histopathological patterns differ from those of adults. Case presentation A 13-year-old boy with a gastrointestinal stromal tumor was characterized by a rare genetic mutation. The patient complained of “fatigue with intermittent abdominal pain for 1 month”. According to the preoperative imaging examination, gastroscopy, and gastroscopic biopsy, the patient was diagnosed with a gastric stromal tumor. Postoperative pathology showed that the tumor cells were fusiform and ovoid, and mitotic figures were easily seen. Immunohistochemistry revealed that the tumor was S-100(+), SOX10(−), CD34(+), SMA(partially+), DOG-1(+), CD117(+), KI-67 (positive for 20% + of the subjects and 40% + of the hotspots), and SDHB(−). Genetic tests showed missense mutations in ALK and TSC1. With surgical treatment, the tumor was completely removed. The patient recovered well and was discharged on the ninth day after the operation. He is currently under follow-up. Conclusions In this case involving a patient with a gastrointestinal stromal tumor, immunohistochemistry indicated that the tumor was an "SDH-deficient type", and gene detection showed no KIT or PDGFRA mutation but rare ALK and TSC1 mutations, which adds to the knowledge of the types of gene mutations in children with gastrointestinal stromal tumors.

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