scholarly journals Prostate Specific Antigen: A Diagnostic Marker in Polycystic Ovarian Syndrome

2019 ◽  
Author(s):  
Kiran Bhat ◽  
Meena Bhandari ◽  
Vaishali Garg
Keyword(s):  
Prostate Specific Antigen ◽  
Polycystic Ovarian Syndrome ◽  
Diagnostic Marker ◽  
Specific Antigen ◽  
Antigen A ◽  
Ovarian Syndrome

The Value of Prostate-Specific Antigen in Diagnosis of Polycystic Ovarian Syndrome in Adolescent Girls

2018 ◽  
Vol 31 (3) ◽  
pp. 263-269 ◽  
Author(s):  
Aytekin Tokmak ◽  
Serkan Bodur ◽  
Selcuk Erkilinc ◽  
Sule Ozel ◽  
Yaprak Engin-Ustun
Keyword(s):  
Prostate Specific Antigen ◽  
Adolescent Girls ◽  
Polycystic Ovarian Syndrome ◽  
Specific Antigen ◽  
Ovarian Syndrome

scholarly journals Serum complexed and free prostate-specific antigen (PSA) for the diagnosis of the polycystic ovarian syndrome (PCOS)

2017 ◽  
Vol 55 (11) ◽  
Author(s):  
Eleftherios P. Diamandis ◽  
Frank Z. Stanczyk ◽  
Sarah Wheeler ◽  
Anu Mathew ◽  
Martin Stengelin ◽  
...  
Keyword(s):  
Prostate Specific Antigen ◽  
Polycystic Ovarian Syndrome ◽  
Characteristic Curve ◽  
Specific Antigen ◽  
Disease Diagnosis ◽  
Cross Sectional Study ◽  
Total Testosterone ◽  
Cross Sectional ◽  
Free Psa ◽  
Ovarian Syndrome

AbstractBackground:Polycystic ovarian syndrome (PCOS) is a common cause of reproductive and metabolic dysfunction. We hypothesized that serum prostate-specific antigen (PSA) may constitute a new biomarker for hyperandrogenism in PCOS.Methods:We conducted a cross-sectional study of 45 women with PCOS and 40 controls. Serum from these women was analyzed for androgenic steroids and for complexed PSA (cPSA) and free PSA (fPSA) with a novel fifth- generation assay with a sensitivity of ~10 fg/mL for cPSA and 140 fg/mL for fPSA.Results:cPSA and fPSA levels were about three times higher in PCOS compared to controls. However, in PCOS, cPSA and fPSA did not differ according to waist-to-hip ratio, Ferriman-Gallwey score, or degree of hyperandrogenemia or oligo-ovulation. In PCOS and control women, serum cPSA and fPSA levels were highly correlated with each other, and with free and total testosterone levels, but not with other hormones. Adjusting for age, body mass index (BMI) and race, cPSA was significantly associated with PCOS, with an odds ratio (OR) of 5.67 (95% confidence interval [CI]: 1.86, 22.0). The OR of PCOS for fPSA was 7.04 (95% CI: 1.65, 40.4). A multivariate model that included age, BMI, race and cPSA yielded an area-under-the-receiver-operating-characteristic curve of 0.89.Conclusions:Serum cPSA and fPSA are novel biomarkers for hyperandrogenism in PCOS and may have value for disease diagnosis.

scholarly journals Is serum prostate-specific antigen a diagnostic marker for benign and malignant breast tumors in women?

2015 ◽  
Vol 6 (1) ◽  
pp. 15 ◽  
Author(s):  
Alireza Abdollahi ◽  
Saeed Shoar ◽  
Ramesh Omranipour ◽  
SeyedHasan Emami Razavi ◽  
Mahsa Ghajarzadeh
Keyword(s):  
Prostate Specific Antigen ◽  
Diagnostic Marker ◽  
Specific Antigen ◽  
Breast Tumors ◽  
Serum Prostate Specific Antigen ◽  
Malignant Breast ◽  
Antigen A

scholarly journals Role of insulin sensitising agents in altering PSA level in PCOS

2017 ◽  
Vol 6 (11) ◽  
pp. 4986 ◽  
Author(s):  
Rajashree Panigrahy ◽  
Bratati Singh ◽  
Tapan K. Pattnaik ◽  
Sanjukta Misra
Keyword(s):  
Insulin Resistance ◽  
Polycystic Ovarian Syndrome ◽  
Specific Antigen ◽  
Serum Testosterone ◽  
Healthy Controls ◽  
Androgen Excess ◽  
Control Serum ◽  
Ovarian Syndrome ◽  
Significant Concentration

Background: Ovarian androgen production can be promoted by insulin resistance which leads to reproductive abnormalities in Polycystic Ovarian Syndrome (PCOS). A wide variety of female tissues can synthesize and secrete Prostate Specific Antigen (PSA). Androgens may take part a significant role in PSA secretion in PCOS. As insulin resistance stimulates androgen production, the baseline value of PSA may decline by insulin sensitising agents in PCOS. Present study is an attempt to measure the function of PSA as a marker of androgen excess in PCOS and to assess the role of insulin sensitising agent metformin in altering PSA level in PCOS.Methods: The study was undertaken to assess the insulin resistance, testosterone and PSA level in 45 women diagnosed as PCOS and 45 healthy controls. Alteration of insulin resistance, serum testosterone and PSA levels by metformin was also analysed.Results: A significant increase in testosterone, PSA level and insulin resistance was observed in PCOS cases when compared with control (p<0.001). When metformin was given for 4 months, improvement in insulin resistance and testosterone level was found in cases, but PSA values observed no change. Correlation was not found linking insulin resistance with PSA level prior to and after therapy.Conclusions: Serum PSA level could be detected in high significant concentration in PCOS women. Various researches explain that insulin resistance and BMI may perhaps control serum PSA level, but our result demonstrate no effect of insulin sensitising agent on serum PSA value.

A microfluidic immunoassay platform for the detection of free prostate specific antigen: a systematic and quantitative approach

The Analyst ◽  
2015 ◽  
Vol 140 (13) ◽  
pp. 4423-4433 ◽  
Author(s):  
Narayanan Madaboosi ◽  
Ruben R. G. Soares ◽  
Virginia Chu ◽  
João Pedro Conde
Keyword(s):  
Prostate Specific Antigen ◽  
Specific Antigen ◽  
Quantitative Approach ◽  
Free Psa ◽  
Microfluidic Immunoassay ◽  
Antigen A ◽  
Relevant Range

A novel physisorption- and bio-affinity amplification-based microfluidic immunoassay platform for free PSA detection within a clinically relevant range is reported.

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