scholarly journals Primary Thyroid Lymphoma in an Adult Male: A Rare Presentation

2020 ◽  
Author(s):  
Poonam Dambhare-Wasnik ◽  
Ashish Kumar Gupta
Keyword(s):  
B Cell ◽  
Histopathological Examination ◽  
False Negative ◽  
B Cell Lymphoma ◽  
Needle Aspiration ◽  
Chronic Lymphocytic Thyroiditis ◽  
Thyroid Lymphoma ◽  
Rare Presentation ◽  
Primary Thyroid Lymphoma ◽  
Needle Aspiration Cytology

Primary Thyroid Lymphoma (PTL) is a rare entity prevalent in middle to old aged females. They are predominantly B-cell Non-Hodgkin’s Lymphoma (NHL), among which Diffuse Large B-Cell Lymphoma (DLBCL) is the most common subtype. Here, the authors have described a case of PTL in a male patient which is extremely rare. The patient presented with a swelling over anterior aspect of neck and dysphagia since two months. Fine Needle Aspiration Cytology (FNAC) of thyroid swelling and following immunocytochemistry showed B-cell NHL. Histopathological and Immunohistochemical (IHC) examination was also done thereafter on right hemithyroidectomy specimen, which revealed a non-germinal centre type of DLBCL. Histopathological examination revealed an antecedent chronic lymphocytic thyroiditis in this patient. With this case, it was evident that early diagnosis of thyroid lymphoma can be possible with FNAC. However, false negative diagnosis can occur on non-representative aspiration sample. Besides this, it is challenging for a pathologist to subtype the lymphoma on cytology smear. Hence, histopathological examination along with Immunohistochemistry (IHC) is imperative for accurate diagnosis of PTL. The patient had received three cycles of chemotherapy and follow-up of 11 months was uneventful.

scholarly journals Sarcoidosis-Lymphoma Syndrome Associated With Primary Thyroid Lymphoma: A Case Report

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. A900-A900
Author(s):  
Saori Yamashita ◽  
Yayoi Matsuda ◽  
Hiroki Muta ◽  
Toshihiko Nagao ◽  
Hiroshi Nakao ◽  
...  
Keyword(s):  
Thyroid Gland ◽  
B Cell ◽  
Clinical Symptoms ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
High Grade ◽  
Thyroid Lymphoma ◽  
Chronic Thyroiditis ◽  
Primary Thyroid Lymphoma ◽  
High Grade Transformation

Abstract Background: Sarcoidosis is occasionally accompanied by hematologic malignancies, including lymphoma, called sarcoidosis-lymphoma syndrome. Although the mechanism underlying the induction of lymphomas is still unknown, understanding the immunological background of sarcoidosis could help explain the possible mechanisms of the induction of lymphomas. Case Presentation: A 52-year-old woman was diagnosed chronic thyroiditis with normal thyroid function. One year later, she underwent a screening chest radiograph and identified bilateral hilar adenopathy and mediastinum lymphadenopathy. Subsequent mediastinoscopy demonstrated sarcoidosis. Because of the lack of clinical symptoms, steroid treatment was not initiated and regular follow-up was performed. One and a half years after the diagnosis of chronic thyroiditis, she presented with rapid swelling of the thyroid gland. FDG-PET/CT showed intense uptake of FDG in the thyroid gland and multiple lymphadenopathy. Fine-needle aspiration (FNA) cytology of the thyroid gland was only suggestive of a lymphoproliferative disorder and did not provide a definitive diagnosis. Partial thyroidectomy was performed, and the pathology indicated diffuse large B-cell lymphoma (DLBCL) such as high-grade transformation of extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) lymphoma. The results of an examination of a paraffin block histopathology specimen by fluorescence in-situ hybridization (FISH) detected BCL6 rearrangement (3q27), which is the most common chromosomal abnormality in DLBCL. After the treatment with R-EPOCH (rituximab, etoposide, vincristine, doxorubicin, cyclophosphamide, and prednisone) chemotherapy, the thyroid gland enlargement has improved markedly, while the lymph nodes remained swelling, that suggested lymph node involvements were due to sarcoidosis. Conclusions: Rapid swelling of the thyroid gland in the setting of chronic thyroiditis should raise suspicion for thyroid lymphoma. Furthermore, our present case might suggest that sarcoidosis accelerate the development and high-grade transformation of thyroid lymphoma. To our knowledge, this is the first reported case of sarcoidosis and primary thyroid lymphoma in the same patient.

scholarly journals Primary Thyroid Lymphoma

2012 ◽  
Vol 27 (1) ◽  
pp. 38-40
Author(s):  
Claudine Ann Musngi-Paras ◽  
Ansarie P. Salpin ◽  
Januario D. Veloso
Keyword(s):  
B Cell ◽  
Marginal Zone ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Lymphoid Cells ◽  
Follicular Epithelium ◽  
Thyroid Lymphoma ◽  
Large B Cell Lymphoma ◽  
Primary Thyroid Lymphoma ◽  
Large B Cell

Eight cases of primary thyroid lymphoma were reported in a tertiary government hospital from January 2005 to August 2011. All patients presented with a diffuse enlargement of both thyroid lobes with associated obstructive symptoms. Five of these cases were extranodal marginal zone lymphoma and three were diffuse large B-cell lymphoma. Clinical features that would favor a thyroid lymphoma include tumor size of greater that 7cm, obstructive symptoms, clinical hypothyroidism or history of Hashimoto thyroiditis. Thus, these features must be considered in evaluating thyroid nodules during fine-needle aspiration biopsy. Histologically, extranodal marginal zone B-cell lymphoma shows vaguely nodular to diffuse infiltrates of small to intermediate size atypical lymphoid cells infiltrating the thyroid follicles, while diffuse large B-cell lymphoma shows sheets of large atypical lymphoid cells infiltrating the thyroid follicular epithelium. Keywords: Primary Thyroid Lymphoma, Extranodal Marginal Zone B-cell Lymphoma, Diffuse Large B-cell Lymphoma.

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