scholarly journals Use of Dexmedetomidine as an Adjuvant to Propofol along with Neurophysiological Monitoring of the Seventh Cranial Nerve during Cerebello- Pontine Tumour Excision Surgery

Author(s):  
Pooja Arpan Shah ◽  
Gayatri Vasagadekar ◽  
Akhilesh Chhaya

Cerebello‑Pontine Angle (CPA) surgeries are very challenging for neurosurgeons as it lies very close to brain stem so various cranial nerves are at risk of damage. Generally, such surgeries require neuromuscular monitoring of various cranial nerves. For that we have to discontinue neuromuscular blocking agents and inhalational agents. Total Intravenous Anaesthesia (TIVA) avoids the use of neuromuscular blocking agents as well as inhalational agents. However, prolonged infusion of propofol is associated with risks, such as hypotension, delayed awakening, and metabolic acidosis, known as “Propofol Infusion Syndrome”. Dexmedetomidine now‑a‑days is used very commonly as an adjuvant to propofol and it significantly reduces the anaesthetic requirement. Addition of dexmedetomidine provides haemodynamic stability during such neurosurgeries. Here, authors have described anaesthetic management of a 46‑year‑old female patient posted for CPA excision along with seventh cranial nerve monitoring using dexmedetomidine with propofol.

2021 ◽  
pp. 0310057X2096857
Author(s):  
Brian L Erstad ◽  
Jeffrey F Barletta

There is no consensus on which weight clinicians should use for weight-based dosing of neuromuscular blocking agents (NMBAs), as exemplified by differing or absent recommendations in clinical practice guidelines. The purpose of this paper is to review studies that evaluated various size descriptors for weight-based dosing of succinylcholine and non-depolarising NMBAs, and to provide recommendations for the descriptors of choice for the weight-based dosing of these agents in patients with obesity. All of the studies conducted to date involving depolarising and non-depolarising NMBAs in patients with obesity have assessed single doses or short-term infusions conducted in perioperative settings. Recognising that any final dosing regimen must take into account patient-specific considerations, the available evidence suggests that actual body weight is the size descriptor of choice for weight-based dosing of succinylcholine and that ideal body weight, or an adjusted (or lean) body weight, is the size descriptor of choice for weight-based dosing of non-depolarising NMBAs.


2009 ◽  
Vol 24 (1) ◽  
pp. 50-57 ◽  
Author(s):  
Cynthia A. Lien ◽  
Peter Savard ◽  
Matthew Belmont ◽  
Hiorshi Sunaga ◽  
John J. Savarese

1957 ◽  
Vol 9 (1) ◽  
pp. 1004-1016 ◽  
Author(s):  
D. Edwards ◽  
J. J. Lewis ◽  
J. B. Stenlake ◽  
M. S. Zoha

2016 ◽  
Vol 30 (5) ◽  
pp. e45-e46
Author(s):  
Marina Pieri ◽  
Alessandro Belletti ◽  
Giovanni Affronti ◽  
Veronica Dalessandro ◽  
Ada Carla Alba ◽  
...  

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