scholarly journals DEVELOPMENT AND VALIDATION OF STABILITY INDICATING ASSAY METHOD FOR SIMULTANEOUS ESTIMATION OF ILAPRAZOLE AND DOMPERIDONE IN BULK AND SOLID DOSAGE FORM BY UV-SPECTROSCOPY

2016 ◽  
Vol 7 (9) ◽  
pp. 26-31 ◽  
Author(s):  
Ram S Sakhare ◽  
Sanjay S Pekamwar ◽  
Sujata D Dhamane ◽  
Anagha G Sujalegaonkar
Keyword(s):  
Dosage Form ◽  
Uv Spectroscopy ◽  
Assay Method ◽  
Simultaneous Estimation ◽  
Stability Indicating ◽  
Solid Dosage Form ◽  
Solid Dosage ◽  
Development And Validation

scholarly journals Method Development and Validation of Stability Indicating Assay for Risperidone in Solid Dosage Form by Using HPTLC

2017 ◽  
Vol 29 (1) ◽  
pp. 99-103
Author(s):  
Sunil Singh ◽  
Rajiv Dahiya ◽  
Jay Ram Patel ◽  
Sanjeev Kumar Sahu ◽  
Shailesh Kumar Gupta
Keyword(s):  
Dosage Form ◽  
Method Development ◽  
Stability Indicating ◽  
Solid Dosage Form ◽  
Solid Dosage ◽  
Method Development And Validation ◽  
Development And Validation

scholarly journals A NEW ROBUST ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF RIBOCICLIB AND LETROZOLE IN SOLID DOSAGE FORM (TABLET)

2021 ◽  
pp. 129-134
Author(s):  
BHAGYALATA SATAPATHY ◽  
CHAITANYA BANGARI
Keyword(s):  
Analytical Method ◽  
Dosage Form ◽  
Method Development ◽  
Simultaneous Estimation ◽  
Solid Dosage Form ◽  
Solid Dosage ◽  
Ich Guidelines ◽  
Method Development And Validation ◽  
Development And Validation ◽  
Tablet Dosage

Objective: The objective of the study was to develop a new robust, sensitive, precise, accurate RP-HPLC analytical method and validate for simultaneous estimation of ribociclib and letrozole in solid dosage form (tablet). Methods: The chromatographic separation was carried out on Waters, symmetry C18 (150 mm×4.6 mm with 3.5 μm), mobile phase used was a mixture of buffer and acetonitrile in the ratio of 80:20, with flow rate of 1ml/min and injection volume of 10 μL for the assay. The detection was done using PDA at 260 nm, with run time of 5 min. The retention time for the drugs ribociclib and letrozole was detected to be 2.648 min and 3.151 min, respectively. The method was validated according to ICH guidelines. Results: The linearity of letrozole and ribociclib was observed to be in the range of 0.50–7.50 and 40.01–600.15, Correlation coefficient (r2) 0.999 and 0.9983, respectively. Accuracy for ribociclib and letrozole is carried out by repeatable concentrations of 50%, 100%, and 150. Validation factors of robustness and ruggedness were detected to be in limits. Conclusion: The developed method was simple, rapid, and consistent; it can be used for the simultaneous estimation of ribociclib and letrozole tablet dosage form in routine analysis.

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