INTERACTION OF SOME ANTIBIOTICS WITH SEMIORGANIC IODINE ADDUCTS

Лекарственная устойчивость к антибиотикам вызвала необходимость поиска новых лекарственных средств и лекарственных форм. Известно, что семиорганические аддукты иода обладают широким спектром антимикробного действия. Эти же соединения, содержащие в своем составе молекулу галогена - иода, могут выступать в качестве галогенирующего агента в отношении антибиотиков. Изучено взаимодействие антибиотиков тетрациклина, гентамицина, хлорамфеникола, относящихся к классам поликетидов, аминогликозидов и амфениколов, соответственно, с аддуктом иода методами рефрактометрии, УФ-спектроскопии и ИК-спектроскопии. Показано, что антибиотик хлорамфеникол не взаимодействует с семиорганическим аддуктом иода ди2-аминопропионовой кислоты дитрииодоводород моногидратом (субстанция D1). Antibiotic drug resistance has necessitated the search for new drugs and dosage forms. It is known that semiorganic iodine adducts have a wide spectrum of antimicrobial effects. The same compounds containing a halogen-iodine molecule may act as a antibiotics halogenating agent. The interaction of antibiotics tetracycline, gentamicin, chloramphenicol belonging to the classes of polyketides, aminoglycosides and amphenicols, respectively, with iodine adduct by refractometry, UV spectroscopy and IR spectroscopy was studied. It has been shown that the antibiotic chloramphenicol does not interact with the semiorganic adduct of di-2-aminopropionic acid ditriiodinehydride monohydrate (D1 substance).

Phosphanchalkogenide und ihre Metallkomplexe. III. Halogenierungsprodukte der Gold(I)komplexe Ph3PEAuX (E = S oder Se; X = Cl, Br oder I)

The complexes Ph3PEAuI (E = S, Se; 1, 2) were obtained from the reaction of Ph3PEAuCl with KI; they are appreciably less stable than their chloro and bromo analogues. The X-ray structures were determined, whereby 1 proved to be contaminated by a small amount of Ph3PS·I2. Oxidation of 1 and 2 with elemental iodine led to the adducts Ph3PEAuI·0.5I2 (3 and 4), but X-ray investigation of a crystal initially assumed to be 3 proved it to be a 1:1 mixture of 3 with the adduct Ph3PS·1.5I2, while in 4 the iodine molecule was severely disordered, which prevented successful refinement of the structure. Decomposition of 4 by loss of gold led to Ph3PSeI2·1.5I24a. Complexes Ph3PEAuX (E = S, Se; X = Br, Cl) were oxidized by elemental bromine (X = Br) or PhICl2 (X = Cl) to Ph3PEAuX3 (5, 6, 9, 10); none of these X-ray structures could be refined satisfactorily because of diffuse scattering phenomena. Further oxidation led to the ionic compounds [Ph3PEX]+ [AuX4]– (X = Br, E = S, Se: 7, 8; X = Cl, E = S, 11) or [Ph3PSeCl]+ 0.5[Au4Cl10Se2]2– (12), containing the novel groupings P–E–X. X-ray structures confirmed the nature of all four of these compounds, which display longer P–E bonds than the gold(I) starting materials and short X···X and/or E···X contacts between cations and anions.