Channelopathies is group of diseases which is concerned with changes occur in the structural unit i.e., cell and its subunits (channels).
Particularly disturbances in equilibrium potential in cell membrane carry toward the major cause of disease. Study of channel
physiology with its mechanism is essential methodology to establish the differential factor in between normal phenomenon and
disorder. Specific channels permit movement of selected ions through cellular membranes and are of important importance during
variety of physiological processes, particularly in excitable tissues. In this review channelopathies in diseases like Central nervous
system, Cardiovascular system, Renal system with their mechanism of action of channel disruption and treatment approaches have
been covered.