A Metal-Free Approach for Brønsted Acid Promoted C–H Alkyl­ation of Heteroarenes with Alkyl Peroxides

A metal-free protocol for Minisci C–H alkylation of hetero­arenes using alkyl peroxides as the alkylating reagents and internal oxidants simultaneously under promotion of Brønsted acid has been demonstrated. A series of alkyl substituted heteroarenes were readily prepared by the C–H alkylation in moderate to good yields. A possible pathway involving the addition of alkyl radical to heterocycle followed by rearomatization is described.

Iron catalyzed methylation and ethylation of vinyl arenes

Iron-catalyzed methyl, ethyl and propyl Heck reactions were developed using readily available alkyl peroxides as alkyl sources.