Contrast effect of emotional context on interpersonal distance with neutral social stimuli

In social interactions, valence-based judgements are an important component of interpersonal distances regulation. Within the framework of the Range-Frequency model, we tested whether the emotional context, which is known to produce a contrast effect on valence ratings, also contributes to the regulation of interpersonal distances. 51 participants divided in two groups were shown virtual characters with either a neutral facial expression (target-stimuli) or an emotional facial expression (contextual stimuli) in two successive sessions (angry then happy emotional context or vice-versa). The participants rated the valence of the virtual characters and judged the appropriateness of different interpersonal distances. For neutral characters, contrast effect of emotional context was observed, albeit only subtly on interpersonal distance judgments. Overall, the data suggest that although the emotional context influences valence-based judgments of social stimuli, it has a parsimonious effect on interpersonal distance regulation, presumably because the latter relies primarily on emotional facial expression categorical-information.

TSC1 as a Novel Gene for Sleep-Related Hypermotor Epilepsy: A Child with a Mild Phenotype of Tuberous Sclerosis

Sleep-related hypermotor epilepsy (SHE) is a rare syndrome that presents with hyperkinetic asymmetric tonic/dystonic seizures with vegetative signs, vocalization, and emotional facial expression, mainly during light non-rapid eye movement sleep stages. The role of various genes (CHRNA4, CHRNB2, CHRNA2, KCNT1, DEPDC5, NPRL2, NPRL3, and PRIMA1) has previously been reported, though genetic etiology is assessed in less than 10% of cases. We report the case of a 5-year-old female carrying the TSC1 variant c.843del p.(Ser282Glnfs*36) who presented with a mild phenotype of tuberous sclerosis, including carbamazepine-responsive SHE, normal neurocognitive functioning, hypomelanotic macules, no abnormalities outside the central nervous system, and tubers at neuroimaging. The presented case extends the list of SHE-related genes to include TSC1, thus suggesting a central pathogenic role of mammalian target of rapamycin (mTOR) cascade dysfunction in SHE and introducing a possible use of mTOR inhibitors in this epileptic syndrome.