Schwanomma of the Left Iliohypogastric Nerve: A Case Report and Technical Consideration

Schwannomas are encapsulated tumors arising from Schwann cells of the nerve sheath, and are usually solitary sporadic lesions. The schwannoma of the ilio-hypogastric nerve especially in the retro-petoneal space is very rare. We are reporting a case of the schwannoma of the left ilio-hypagastric nerve over the psoas muscle. The diagnosis was done by ultarsonogrsphy and MRI. The histopathological study confirmed the diagnosis. The tumour was excised through retro-peritoneal approach. By this approach total excision of the tumour with preservation of ilio-hypogastric nerve is possible. Journal of Science Foundation 2019;17(2):71-74

Effects of Intravesical Prostaglandin E2 on Bladder Function are Preserved in Capsaicin-Desensitized Rats

Prostaglandin E2 (PGE2) instilled into the bladder generates symptoms of urinary urgency in healthy women and reduces bladder capacity and urethral pressure in both humans and female rats. Systemic capsaicin desensitization, which causes degeneration of C-fibers, prevented PGE2 mediated reductions in bladder capacity, suggesting that PGE2 acts as an irritant (Maggi et al.1988). In the present study, we instilled PGE2 in female rats after capsaicin desensitization, but without the hypogastric nerve transection that was conducted in the Maggi et al. study. One week after capsaicin injection (125 mg/kg, SC) rats underwent cystometric and urethral perfusion testing under urethane anesthesia with saline and 100 µM PGE2. Similar to naïve rats, capsaicin-desensitized rats exhibited a reduction in bladder capacity from 1.24 ± 0.13 ml to 0.70 ± 0.10 ml (P=0.002, n=9), a reduction in urethral perfusion pressure from 19.3 ± 2.1 cmH2O to 10.9 ± 1.15 cmH2O (P=0.004, n=9), and a reduction in bladder compliance from 0.13 ± 0.020 ml/cmH2O to 0.090 ± 0.014 ml/cmH2O (P=0.011, n=9). Thus, changes in bladder function following the instillationof PGE2 were not dependent on capsaicin-sensitive pathways. Further, these results suggest that urethral relaxation/weakness and/or increased detrusor pressure as a result of decreased compliance may contribute to urinary urgency and highlight potential targets for new therapies for overactive bladder.