Macular and Peripapillary Choroidal Thickness Measured by Enhanced Depth Imaging Optical Coherence Tomography in Chinese Pregnant Women and Healthy No-Pregnant Women
Abstract Purpose: To evaluate macular, peripapillary choroidal thickness and retinal nerve fiber layer (RNFL) thickness in different trimesters and compare the measurements with those of healthy non-pregnant women. Methods: A prospective comparative study included 45 healthy pregnant women in first trimester, 90 women in second, 45 women in third trimesters and 45 healthy no-pregnant women as the control group. Macular choroidal thickness was measured at the subfoveal, 1mm temporal and 1mm nasal to the fovea using enhanced depth imaging optical coherence tomography (EDI-OCT). Peripapillary choroidal thickness and RNFL thickness parameters were automatically calculated by the Spectralis OCT. These parameters were analyzed among groups. Results: The subfoveal, temporal and nasal choroidal thickness were all significantly thicker in second trimesters, comparing with those parameters in first, third trimesters and the control group (all P<0.05). The peripapillary choroidal thickness was significantly increased at temporal, nasal, nasal inferior, temporal inferior and global positions during pregnancy among the 4 groups (all P<0.05). The RNFL thickness was also significantly increased in pregnant women at nasal superior and nasal inferior quadrants.Conclusions: Our results suggested that macular choroidal thickening appeared in second trimester. And peripapillary choroidal thickness and RNFL thickness also became thickening in pregnant women comparing with no-pregnant women as a whole.