cortical computation
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2020 ◽  
Vol 22 (1) ◽  
pp. 21-37
Author(s):  
Sadra Sadeh ◽  
Claudia Clopath
Keyword(s):  

Neuron ◽  
2018 ◽  
Vol 100 (2) ◽  
pp. 424-435 ◽  
Author(s):  
Georg B. Keller ◽  
Thomas D. Mrsic-Flogel

2017 ◽  
Author(s):  
Thomas Pfeffer ◽  
Arthur-Ervin Avramiea ◽  
Guido Nolte ◽  
Andreas K. Engel ◽  
Klaus Linkenkaer-Hansen ◽  
...  

ABSTRACTThe ascending modulatory systems of the brainstem are powerful regulators of global brain state. Disturbances of these systems are implicated in several major neuropsychiatric disorders. Yet, how these systems interact with specific neural computations in the cerebral cortex to shape perception, cognition, and behavior remains poorly understood. Here, we probed into the effect of two such systems, the catecholaminergic (dopaminergic and noradrenergic) and cholinergic systems, on an important aspect of cortical computation: its intrinsic variability. To this end, we combined placebo-controlled pharmacological intervention in humans, magnetoencephalographic (MEG) recordings of cortical population activity, and psychophysical measurements of the perception of ambiguous visual input. A low-dose catecholaminergic, but not cholinergic, manipulation altered the rate of spontaneous perceptual fluctuations as well as the temporal structure of “scale-free” population activity of large swaths of visual and parietal cortex. Computational analyses indicate that both effects were consistent with an increase in excitatory relative to inhibitory activity in the cortical areas underlying visual perceptual inference. We propose that catecholamines regulate the variability of perception and cognition through dynamically changing the cortical excitation-inhibition ratio. The combined read-out of fluctuations in perception and cortical activity we established here may prove useful as an efficient, and easily accessible marker of altered cortical computation in neuropsychiatric disorders.


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