rna trafficking
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2021 ◽  
pp. 29-37
Author(s):  
Heather N. Smith ◽  
Junfei Ma ◽  
Ying Wang
Keyword(s):  

2021 ◽  
Vol 49 (18) ◽  
pp. 10630-10643
Author(s):  
Yimin Wang ◽  
Jing Fan ◽  
Jianshu Wang ◽  
Yi Zhu ◽  
Lin Xu ◽  
...  

Abstract Controlling proper RNA pool for nuclear export is important for accurate gene expression. ZFC3H1 is a key controller that not only facilitates nuclear exosomal degradation, but also retains its bound polyadenylated RNAs in the nucleus upon exosome inactivation. However, how ZFC3H1 retains RNAs and how its roles in RNA retention and degradation are related remain largely unclear. Here, we found that upon degradation inhibition, ZFC3H1 forms nuclear condensates to prevent RNA trafficking to nuclear speckles (NSs) where many RNAs gain export competence. Systematic mapping of ZFC3H1 revealed that it utilizes distinct domains for condensation and RNA degradation. Interestingly, ZFC3H1 condensation activity is required for preventing RNA trafficking to NSs, but not for RNA degradation. Considering that no apparent ZFC3H1 condensates are formed in normal cells, our study suggests that nuclear RNA degradation and retention are two independent mechanisms with different preference for controlling proper export RNA pool—degradation is preferred in normal cells, and condensation retention is activated upon degradation inhibition.


2020 ◽  
Vol 118 (3) ◽  
pp. 573a
Author(s):  
Andreas Schmidt ◽  
Ameya P. Jalihal ◽  
Guoming Gao ◽  
Nils G. Walter

2020 ◽  
Vol 118 (3) ◽  
pp. 467a-468a
Author(s):  
Guoming Gao ◽  
Ameya P. Jalihal ◽  
Andreas Schmidt ◽  
Nils G. Walter

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