growth hormone secretagogue receptors
Recently Published Documents


TOTAL DOCUMENTS

14
(FIVE YEARS 0)

H-INDEX

7
(FIVE YEARS 0)

2012 ◽  
Vol 176 (1-3) ◽  
pp. 28-35 ◽  
Author(s):  
Hiroaki Nunoi ◽  
Bunzo Matsuura ◽  
Sachiko Utsunomiya ◽  
Teruhisa Ueda ◽  
Teruki Miyake ◽  
...  


2010 ◽  
Vol 235 (4) ◽  
pp. 463-469 ◽  
Author(s):  
Ignacio A Gómez de Segura ◽  
María Teresa Vallejo-Cremades ◽  
Jesús Lomas ◽  
Miriam F Sánchez ◽  
María Isabel Caballero ◽  
...  

Ghrelin is the natural endogenous ligand for growth hormone secretagogue receptors. This peptide regulates energy homeostasis and expenditure and is a potential link between gut absorptive function and growth. We hypothesized that ghrelin may induce a proliferative and antiapoptotic action promoting the recovery of the hypotrophic gut mucosa. Therefore, the aim of the study was to determine the action of exogenous ghrelin following gut mucosal hypotrophia in rats fed an elemental diet. An elemental diet provides readily absorbable simple nutrients and is usually given to patients with absorptive dysfunction. Male Wistar rats ( n = 48) were fed the elemental diet for one week to induce mucosal hypotrophy and then treated for another week with systemic ghrelin and pair-fed with either a normoproteic or hyperproteic isocaloric liquid diet. Another group received a standard diet instead of the elemental diet and served as control (normotrophy). The elemental diet induced intestinal hypotrophia characterized by decreased proliferation in the ileum and increased apoptosis in jejunum and ileum. Ghrelin administration restored normal levels of proliferation in the ileum and apoptosis in the jejunum, with partial apoptosis restoration in the ileum. Ghrelin levels in plasma and fundus were increased in all groups, although the highest levels were found in rats treated with exogenous ghrelin. Ghrelin administration has a positive effect in the hypotrophic gut, regulating both proliferation and apoptosis towards a physiological balance counteracting the negative changes induced by an elemental diet in the intestines.



2007 ◽  
Vol 86 (3) ◽  
pp. 147-164 ◽  
Author(s):  
Giampiero Muccioli ◽  
Alessandra Baragli ◽  
Riccarda Granata ◽  
Mauro Papotti ◽  
Ezio Ghigo


2006 ◽  
pp. 27-45 ◽  
Author(s):  
Giampiero Muccioli ◽  
Fabio Broglio ◽  
Elena Tarabra ◽  
Ezio Ghigo


2003 ◽  
pp. 69-84
Author(s):  
Andrew D. Howard ◽  
Scott D. Feighner ◽  
Roy G. Smith ◽  
Lex H. T. Van der Ploeg


Neuroscience ◽  
2003 ◽  
Vol 120 (2) ◽  
pp. 443-453 ◽  
Author(s):  
N.B Dass ◽  
M Munonyara ◽  
A.K Bassil ◽  
G.J Hervieu ◽  
S Osbourne ◽  
...  


Life Sciences ◽  
2003 ◽  
Vol 72 (23) ◽  
pp. 2669-2674 ◽  
Author(s):  
Gabor Halmos ◽  
Andrew V Schally ◽  
Ana Maria Comaru-Schally ◽  
Attila Nagy ◽  
Anand Irimpen


2000 ◽  
pp. 69-84
Author(s):  
Andrew D. Howard ◽  
Scott D. Feighner ◽  
Roy G. Smith ◽  
Lex H. T. Van der Ploeg


Sign in / Sign up

Export Citation Format

Share Document