Machinery components are subjected to dynamic loads. In particular, the fatigue machines must be designed for these types of conditions. On the other hand, the industry demands that it is sought to consume the least amount of raw material for its construction, that is, to optimize. In general, optimization tasks have been carried out mostly by trial and error. In the present work, a redesign of a guide plate of a fatigue machine was carried out based on Topology Optimization. For this purpose, Static Structural, Topology Optimization, Fatigue and Modal Analysis were carried out. With this, a new design is obtained with a reduction in its raw material of 61%. The component was designed for infinite life so that it will not compromise its structural integrity throughout the life of the equipment operation.