In this chapter I develop the complete info-metrics framework for inferring problems and theories under all types of uncertainty and missing information. That framework allows for uncertainty in the observed values and about the functional form, as captured by the constraints. Using the derivations of Chapter 8, it also extends the info-metrics framework to include priors. The basic properties of the complete framework are developed as well. Generally speaking, that framework can be viewed as a “meta-theory”—a theory of how to construct theories and consistent models given the available information. This accrues all the benefits of the maximum entropy formalism but additionally accommodates a larger class of problems. The derivations are complemented with a complete visual representation of the info-metrics framework. Theoretical and empirical applications are provided.