A study of the reaction of 2-pyridyl isothiocyanate with azoimide

From the reaction mixture of 2-pyridyl isothiocyanate with azoimide in dioxane 5-(2-pyridyl-amino)tetrzole, 2-pyridylthiourea and elemental sulfur were isolated instead of the expected 5-(2-pyridylamino)-1,2,3,4-thiatriazole. The mechanism of the reaction mentioned was studied on the basis of the synthesis of the assumed intermediates and the isolation of the intermediates by means of compounds with an activated acetylenic or ethylenic bond.

Steady State Radiolysis of Aqueous Aerated Solutions of 5,6-Dihydrothymine. Identification of the Major Degradation Products

The major radiation-induced degradation products of 5,6-dihydrothymine (1) in aqueous solutions saturated either with O2 or N2O/O2 (75/25 v/v) were identified as thymine (10), the trans-and cis-isomers of 6-hydroperoxy-5,6-dihydrothymine (5, 7), 5-hydroperoxy-5,6-dihydrothymine (9), and their corresponding hydroxy derivatives (4, 6, 8). The formation of these compounds is explained in terms of initial H-abstraction from the C(5) and C(6) carbons which gives rise respectively to the transient 5-yl and 6-yl radicals. Thymine hydroxy-hydroperoxides (11-14) and their decomposition products (17-20), which are derived from hydroxyl radical attack at the 5,6-ethylenic bond of thymine (10), were also characterized.