Antibacterial activity of Mn(i) and Re(i) tricarbonyl complexes conjugated to a bile acid carrier molecule

Mn and Re tricarbonyl bile acid conjugates exhibit low micromolar MIC values and rescue Galleria larvae from bacterial infection.

Properties of the canalicular bile acid transport system in rat liver

4,4-Di-isothiocyanostilbene-2,2′-disulphonic acid inhibition of taurocholate efflux from canalicular vesicles was used to demonstrate that potential driven and ‘carrier’-mediated canalicular excretion of taurocholate occur via a common, rather than two separate, pathways. This electrogenic canalicular bile acid ‘carrier ’ preferentially transports trihydroxylated and conjugated dihydroxylated bile acids, but not the unphysiological oxo bile acids, and possibly extends its substrate specificity to other amphipathic molecules such as sulphobromophthalein.