Gender Differences in Outpatients with Dementia from a Large Psychiatric Hospital in China

Background: The sociodemographic characteristics and clinical features of dementia patients in psychiatric hospitals have not been well discussed in China. This study was to explore gender differences in outpatients with dementia from a psychiatric hospital in China.Methods: This retrospective study examined outpatients with dementia from January 2013 to August 2019 using data in the OMOP common data model (OMOP-CDM) in Beijing Anding Hospital. Age, sex, number of visits, use of drugs and comorbid conditions were recorded by medical records.Results: 9,004 patients were recruited, and the mean number of visits weas 6.92. There were 3,433 (38.13%) male patients and 5,571 (61.87%) female patients. The most common comorbidities were generalized anxiety disorder, nonorganic insomnia, delusional disorder and depressive disorder. The proportion of use of drugs was highest in antidementia (68.30%), followed by benzodiazepines (48.83%), antipsychotics (45.43%), antidepressants (22.24%) and nonbenzodiazepines (19.96%). Patients with dementia showed a significant gender difference in average age (t=6.36, P＜0.0001). Compared to male patients, female patients had a higher number of visits (7.40±12.90 vs 6.15±10.50, t=4.81, P＜0.0001). There were significant differences in comorbidity composition between male and female patients (t=23.09, P＜0.0001).Conclusions: Our present findings suggested significant gender differences in the proportion of age, number of visits and comorbidity composition in outpatients with dementia.

FC12-06 - On the relevance of comorbidity in psychiatry: EEG loreta in generalized anxiety disorder with and without nonorganic Insomnia

IntroductionComorbidity is increasingly regarded as important for both diagnosis and treatment of psychiatric disorders.ObjectivesElectrophysiological neuroimaging such as low-resolution brain electromagnetic tomography (LORETA) may be utilized to obtain insight into the pathogenesis of mental diseases.AimsThe aim of the present study was to compare EEG tomographic data obtained in generalized anxiety disorder (GAD) with and without nonorganic insomnia.MethodsIn the first study, LORETA was performed in 44 untreated patients (25 females) with the primary diagnosis of nonorganic insomnia (F51.0) associated with GAD (F41.1) and 44 age- and sex-matched normal controls. In the second study, 18 patients (9 females) with the primary diagnosis of GAD without mandatory insomnia were compared with 18 controls.ResultsWhile patients with F51.0 and concomitant F41.1 showed an increase in LORETA power in the delta, theta, alpha-1 and alpha-2 frequencies, GAD patients without mandatory insomnia demonstrated a decrease in LORETA power - specifically in delta (more left than right hemisphere, involving occipital cortex, insula, cingulate and frontal cortex) and beta (occipital cortex), mirroring neuroimaging findings on the neural circuitry of anxiety.ConclusionsDifferent EEG LORETA findings were obtained in GAD patients, depending on the comorbidity: While in daytime recordings patients with nonorganic insomnia demonstrated increased slow activities reflecting daytime tiredness and sleepiness, GAD patients without insomnia exhibited a decrease in slow activity and thus hypervigilance. According to the key-lock principle different pharmacological strategies have to be applied, which will be demonstrated on the basis our own data sets.