Synthesis and photophysical properties of 5-(3''-alkyl/aryl-amino-1''-azaindolizin-2''-yl)-2'-deoxyuridines

Groebke-Blackburn-Bienayame (GBB) reaction has been used for the efficient synthesis of novel fluorescent 5-azaindolizino-2'-deoxyuridines starting from commercially available thymidine following two strategies. Thus, thymidine was converted to diacetylthymidine, which on...

An approach towards the synthesis of novel fused nitrogen tricyclic heterocyclic scaffolds via GBB reaction

A concise and efficient one-pot synthesis of novel N-fused tricyclic derivatives has been developed by using the Groebke–Blackburn–Bienaymé (GBB) reaction, which involved the reaction of 3-amino-1H-indazoles, aldehydes and isonitriles to afford 2-aryl-5H-imidazo[1,2-b]indazol-3-amine derivatives via a formal [4 + 1] cycloaddition reaction.

Facile synthesis of 1H-imidazo[1,2-b]pyrazoles via a sequential one-pot synthetic approach

5-Aminopyrazole-4-carbonitrile and ethyl 5-aminopyrazole-4-carboxylate, as potential trifunctional building blocks are introduced in a facile, chemo- and regioselective multicomponent assembly of imidazo[1,2-b]pyrazoles via the Groebke–Blackburn–Bienaymé reaction (GBB reaction). Besides the synthetic elaboration of a green-compatible isocyanide-based access in three-component mode, we describe an operationally simple, one-pot two-step GBB protocol for the rapid construction of a 46 membered imidazo[1,2-b]pyrazole library with yields up to 83%.