glycogen turnover
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2019 ◽  
Vol 99 (1) ◽  
pp. 949-1045 ◽  
Author(s):  
Gerald A. Dienel

Glucose is the long-established, obligatory fuel for brain that fulfills many critical functions, including ATP production, oxidative stress management, and synthesis of neurotransmitters, neuromodulators, and structural components. Neuronal glucose oxidation exceeds that in astrocytes, but both rates increase in direct proportion to excitatory neurotransmission; signaling and metabolism are closely coupled at the local level. Exact details of neuron–astrocyte glutamate–glutamine cycling remain to be established, and the specific roles of glucose and lactate in the cellular energetics of these processes are debated. Glycolysis is preferentially upregulated during brain activation even though oxygen availability is sufficient (aerobic glycolysis). Three major pathways, glycolysis, pentose phosphate shunt, and glycogen turnover, contribute to utilization of glucose in excess of oxygen, and adrenergic regulation of aerobic glycolysis draws attention to astrocytic metabolism, particularly glycogen turnover, which has a high impact on the oxygen–carbohydrate mismatch. Aerobic glycolysis is proposed to be predominant in young children and specific brain regions, but re-evaluation of data is necessary. Shuttling of glucose- and glycogen-derived lactate from astrocytes to neurons during activation, neurotransmission, and memory consolidation are controversial topics for which alternative mechanisms are proposed. Nutritional therapy and vagus nerve stimulation are translational bridges from metabolism to clinical treatment of diverse brain disorders.





2014 ◽  
Vol 2014 ◽  
pp. 1-21 ◽  
Author(s):  
Leif Hertz ◽  
Dan Song ◽  
Baoman Li ◽  
Ting Du ◽  
Junnan Xu ◽  
...  

Chronic treatment with fluoxetine or other so-called serotonin-specific reuptake inhibitor antidepressants (SSRIs) or with a lithium salt “lithium”, carbamazepine, or valproic acid, the three classical antibipolar drugs, exerts a multitude of effects on astrocytes, which in turn modulate astrocyte-neuronal interactions and brain function. In the case of the SSRIs, they are to a large extent due to 5-HT2B-mediated upregulation and editing of genes. These alterations induce alteration in effects of cPLA2, GluK2, and the 5-HT2B receptor, probably including increases in both glucose metabolism and glycogen turnover, which in combination have therapeutic effect on major depression. The ability of increased levels of extracellular K+ to increase [Ca2+]i is increased as a sign of increased K+-induced excitability in astrocytes. Acute anxiolytic drug treatment with benzodiazepines or GABAA receptor stimulation has similar glycogenolysis-enhancing effects. The antibipolar drugs induce intracellular alkalinization in astrocytes with lithium acting on one acid extruder and carbamazepine and valproic acid on a different acid extruder. They inhibit K+-induced and transmitter-induced increase of astrocytic [Ca2+]i and thereby probably excitability. In several cases, they exert different changes in gene expression than SSRIs, determined both in cultured astrocytes and in freshly isolated astrocytes from drug-treated animals.



2011 ◽  
Vol 117 (5) ◽  
pp. 915-926 ◽  
Author(s):  
Dana S. Hutchinson ◽  
Stephanie L. Catus ◽  
Jon Merlin ◽  
Roger J. Summers ◽  
Marie E. Gibbs


2010 ◽  
Vol 318 (1-2) ◽  
pp. 54-60 ◽  
Author(s):  
Kathleen R. Markan ◽  
Michael J. Jurczak ◽  
Matthew J. Brady


2009 ◽  
Vol 55 (1-3) ◽  
pp. 45-51 ◽  
Author(s):  
Florence D. Morgenthaler ◽  
Bernard R. Lanz ◽  
Jean-Marie Petit ◽  
Hanne Frenkel ◽  
Pierre J. Magistretti ◽  
...  


2005 ◽  
Vol 33 (4) ◽  
pp. 157-162 ◽  
Author(s):  
Robert G. Shulman
Keyword(s):  


Author(s):  
Silvia Bradamante ◽  
Andrea Marchesani ◽  
Livia Barenghi ◽  
Luisa Paracchini ◽  
Robert de Jonge ◽  
...  
Keyword(s):  


2000 ◽  
Vol 28 (5) ◽  
pp. A161-A161
Author(s):  
S. Richardson ◽  
A-M. L. Seymour


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