Epulis gravidarum with histological features of plasma cell granuloma associated to herbal toothpaste: A case report

Hormonal imbalance during the pregnancy may predispose a localized gingival enlargement called epulis gravidarum. This paper aims to elaborate on a case of epulis gravidarum with histological features of plasma cell granuloma. Theoretically, they present in different histological features. However, in this case, the histological examinations showed both entities.

PLASMA CELL GRANULOMA IN BUCCAL MUCOSA: A CASE REPORT AND REVIEW OF DIFFERENT CASE REPORTS ON PLASMA CELL GRANULOMA IN ORAL CAVITY

Introduction: 3 Plasma cell granuloma mainly occurs in lungs but can occur in any other organ or soft tissue . It occurs very rarely in oral cavity. We have also reviewed different articles describing plasma cell granuloma in oral cavity. We search the articles in google scholar and pubmed with keywords plasma cell granuloma in oral cavity, buccal mucosa, gingiva, tongue. A Case report: 39 year old male came with a chief complaint of growth on left buccal mucosa. HPE discovered parakeratinized stratied squamous epithelium, showing focal ulceration and underlying dense connective tissue stroma. On the basis of clinicopathological ndings the diagnosis of plasma cell granuloma was made. Discussion: Plasma cell granuloma is a benign lesion but its exact aetiology, behaviour and prognosis is not completely known. We can give emphasis on frozen histopathology intraoperatively to avoid unnecessarily extensive and potentially destructive surgery as the treatment plan.

Gingival Plasma Cell Granuloma: A case Report of Multiple Lesions

Background: Plasma cell granuloma (PCG) is a rare benign pseudotumorous proliferation of unclear etiology that is mainly situated in the lungs. Gingival PCG is an even more peculiar lesion that usually occurs in middle-aged or elderly individuals and clinically manifests as a solitary entity. Case report: A 15-year-old male with no underlying medical conditions presented with multiple gingival masses in the right maxilla, which were initially thought to be epulis. The lesions were resected completely and the excisional biopsies sent for histological examination. Immunohistochemical (IHC) stain revealed dense polyclonal plasma cell infiltration with positive expression of both kappa and lambda light chains, confirming a diagnosis of gingival PCG. Subsequently, the affected gingiva healed uneventfully, with no sign of recurrence over 2 years of follow-up. Conclusions: The present report depicts an extremely unusual case of gingival PCG occurring in a juvenile with multiple lesions, which is worth attention in clinical pediatric dentistry. Excisional-biopsy and histological investigations are imperative for a confirmative diagnosis and to exclude potential aggressive conditions. Complete resection of lesions seems to be a valid treatment, while long-term clinical follow-up is still needed.

A rare case of plasma cell granuloma arising from facial nerve

We present a 38 year old male with a rare case of plasma cell granuloma arising from facial nerve which posed a diagnostic and therapeutic challenge. He has no other comorbidities except for a history of left ear modified radical mastoidectomy performed in 2002 for cholesteatoma after which he recovered uneventfully. This time he presented with mass in the ear canal with ear block and otorrhea for 1 month duration. Initial biopsy revealed granulation tissue. CT scan revealed bony destruction with soft tissue mass. Diagnosis of recurrence of cholesteatoma was made for which he underwent MRM under general anesthesia. Intraoperatively, there was soft tissue mass filling the mastoid and the middle ear and destruction of all ossicles. The mass was arising from facial nerve and there was bony dehiscence of facial nerve. The mass sent for histopathology revealed plasma cell granuloma. He recovered uneventfully with intact facial nerve and hearing level of 40 dB .Ear canal polyp should not be avulsed as it may arise from facial nerve and any mass should be subjected to histopathological examination and should not be left as granulation tissue. This case posed both diagnostic and therapeutic challenge and supported the hypothesis of that plasma cell granuloma are psudotumour and with proper excision and post-operative steroids, there will be complete remission.