Consequences of COVID-19 on future human genetic composition with special emphasis on homeostasis and natural selection

Homeostasis, any self-regulating process by which biological systems tend to maintain stability while adjusting to the condition that is optimal for survival. If homeostasis is effective, life continues; if failed, death succeeds. The stability is a system of dynamic equilibrium, which tends to attain a balance that resists any outside invader that may cause a change. When such a system is disturbed, regulatory genes/immune responds to the departures to establish a new balance; such a process is one of feedback control. There are many kind of homeostasis, among are physiological homeostasis and genetic homeostasis. The first is essential to maintain conditions within restricted limits. Otherwise, the individual will fail to function properly such as body temperature, blood sugar level, blood Pressure and blood pH regulations. On the other hand, genetic homeostasis pertaining to population (may be the whole global population of 7.8 billion) when the gene pool is expressing frequencies of alleles and consequently population genetic frequencies remain the same over a period of time, indicating, the tendency of a population to equilibrate its genetic composition and to resist any changes. In this article it was discussed the consequences of COVID-19, as an evolutionary force of natural selection to the genetic composition of human population. It was concluded that physiological homeostasis are more stable than genetic homeostasis. It was suggested that global population into six genetic categorization for resistant versus susceptible individuals to COVID-19 incidence. Researchers can explore the potential role of genome wide association (GWAS), as molecular genetic markers to be used as early detection of individuals susceptible to COVID-19 to have intensive care.

Neurorehabilitation on the genome level: theoretical principles and experimental prerequisites

The mechanisms of control of genetic homeostasis of neurons and their role in the etiopathogenesis of some neurodegenerative and mental diseases and aging are briefly considered. For the purpose of possible prevention and (or) compensation of these disorders, it is proposed to pharmacologically modulate the activity of systems that ensure the stability of the cell genome.