Constraining theories of gravity by GINGER experiment

The debate on gravity theories to extend or modify general relativity is very active today because of the issues related to ultraviolet and infrared behavior of Einstein’s theory. In the first case, we have to address the quantum gravity problem. In the latter, dark matter and dark energy, governing the large-scale structure and the cosmological evolution, seem to escape from any final fundamental theory and detection. The state of the art is that, up to now, no final theory, capable of explaining gravitational interaction at any scale, has been formulated. In this perspective, many research efforts are devoted to test theories of gravity by space-based experiments. Here, we propose straightforward tests by the GINGER experiment, which, being Earth based, requires little modeling of external perturbation, allowing a thorough analysis of the systematics, crucial for experiments where sensitivity breakthrough is required. Specifically, we want to show that it is possible to constrain parameters of gravity theories, like scalar–tensor or Horava–Lifshitz gravity, by considering their post-Newtonian limits matched with experimental data. In particular, we use the Lense–Thirring measurements provided by GINGER to find out relations among the parameters of theories and finally compare the results with those provided by LARES and Gravity Probe B satellites.

Is It Possible to Personalize the Diagnosis and Treatment of Breast Cancer during Pregnancy?

The main goal of precision medicine in patients with breast cancer is to tailor the treatment according to the particular genetic makeup and the genetic changes in the cancer cells. Breast cancer occurring during pregnancy (BCP) is a complex and difficult clinical problem. Although it is not very common, both maternal and fetal outcome must be always considered when planning treatment. Pregnancy represents a significant barrier to the implementation of personalized treatment for breast cancer. Tailoring therapy mainly takes into account the stage of pregnancy, the subtype of cancer, the stage of cancer, and the patient’s preference. Results of the treatment of breast cancer in pregnancy are as yet not very satisfactory because of often delayed diagnosis, and it usually has an unfavorable outcome. Treatment of patients with pregnancy-associated breast cancer should be centralized. Centralization may result in increased experience in diagnosis and treatment and accumulated data may help us to optimize the treatment approaches, modify general treatment recommendations, and improve the survival and quality of life of the patients.

Management of Somatisers in Primary Care: Are Family Doctors Motivated?

Objective: The aim of this paper is to assess the attitudes of Spanish general practitioners towards somatisers and the degree of involvement that family doctors are ready to adopt in the care of these patients. Method: A postal questionnaire on attitudes was sent to a representative sample (n = 135) of general practitioners from two health districts of the region of Aragon. Seventy (51.8%) of them returned usable questionnaires. Results: Most of the general practitioners were interested in the treatment of somatisers and considered that they should be treated at primary care level. However, when specific treatment tasks were proposed, they only accepted to act as a filter to specialised care and to care for patients with chronic functional syndromes. Additionally, they refuse to detect presenting somatisers, to prescribe psychotropic drugs or offer any psychological approach, and to avoid reinforcing abnormal illness behaviour in these patients and their families. These findings can be explained because the main emotions somatisers produce in doctors are frustration and anger. Conclusions: Family doctors need a lot more help, education and support in the management of somatisers, and psychiatrists need to provide it. Any management program for the treatment of somatisers in primary care should include methods to modify general practitioners' attitudes towards these patients.