scholarly journals Is It Possible to Personalize the Diagnosis and Treatment of Breast Cancer during Pregnancy?

2020 ◽  
Vol 11 (1) ◽  
pp. 18
Author(s):  
Petra Tesarova ◽  
David Pavlista ◽  
Antonin Parizek
Keyword(s):  
Breast Cancer ◽  
Delayed Diagnosis ◽  
Clinical Problem ◽  
Fetal Outcome ◽  
Diagnosis And Treatment ◽  
Genetic Changes ◽  
Planning Treatment ◽  
Cancer In Pregnancy ◽  
Modify General

The main goal of precision medicine in patients with breast cancer is to tailor the treatment according to the particular genetic makeup and the genetic changes in the cancer cells. Breast cancer occurring during pregnancy (BCP) is a complex and difficult clinical problem. Although it is not very common, both maternal and fetal outcome must be always considered when planning treatment. Pregnancy represents a significant barrier to the implementation of personalized treatment for breast cancer. Tailoring therapy mainly takes into account the stage of pregnancy, the subtype of cancer, the stage of cancer, and the patient’s preference. Results of the treatment of breast cancer in pregnancy are as yet not very satisfactory because of often delayed diagnosis, and it usually has an unfavorable outcome. Treatment of patients with pregnancy-associated breast cancer should be centralized. Centralization may result in increased experience in diagnosis and treatment and accumulated data may help us to optimize the treatment approaches, modify general treatment recommendations, and improve the survival and quality of life of the patients.

scholarly journals Management of Ocular Metastasis

1998 ◽  
Vol 5 (4) ◽  
pp. 326-332 ◽  
Author(s):  
William Small
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Metastatic Cancer ◽  
Clinical Problem ◽  
Breast Cancer Patients ◽  
Pertinent Literature ◽  
Intraocular Metastasis ◽  
Ophthalmologic Examination ◽  
Ocular Metastasis

Background Intraocular metastasis is a significant clinical problem in patients with metastatic cancer. The frequency of intraocular metastasis in all patients dying of cancer is approximately 12%, but in breast cancer patients, the frequency can be as high as 37%. Methods A review of pertinent literature and the author's experience are used to describe the epidemiology, diagnosis, and management of metastatic tumors of the eye. Results Intraocular metastases occur frequently and are diagnosed by ophthalmologic examination. Radiotherapy remains the cornerstone of therapy and allows the majority of patients to maintain useful vision for the remainder of their lives. Conclusions The recognition and treatment of intraocular metastasis are important clinical oncologic issues. With proper management, patients with ocular metastasis can maintain vision and thus maximize quality of life.

scholarly journals Living With Metastatic Breast Cancer in Brazil: An In-Depth Analysis of the Patient Journey Through Diagnosis, Treatment, and Quality of Life After Diagnosis

2018 ◽  
Vol 4 (Supplement 2) ◽  
pp. 231s-231s
Author(s):  
L.H.d.C. Barros ◽  
M. Kruse ◽  
N.S.F. Rosa ◽  
R.A. Kaliks ◽  
J.C. Dalri
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Metastatic Breast Cancer ◽  
Metastatic Breast ◽  
The Body ◽  
Diagnosis And Treatment ◽  
Support Network ◽  
Patient Journey ◽  
Depth Analysis

Background: Globally, it is estimated there will be a 43% increase in breast cancer-related deaths from 2015 to 2030, largely as a result of cancer metastasis. Metastatic breast cancer (mBC) is the most advanced stage of breast cancer where the cancer has spread from the original site to other parts of the body. While resources are available for early detection of breast cancer, there is a lack of information and support for those with an advanced breast cancer diagnosis in Brazil. To address this need, Instituto Oncoguia developed the National Metastatic Breast Cancer Patient Support Network, the “More Life Network.” This research is part of the Network initiative and seeks to increase knowledge and support for patients living with mBC. Aim: The aim of this study is to examine the mBC patient journey through diagnosis, treatment and quality of life after diagnosis. Methods: In May 2018, we conducted a cross-sectional study of mBC patients in Brazil. Patients were recruited voluntarily through online platforms. A quantitative online survey instrument was used for data collection. Frequency analysis was conducted across the main subject areas: knowledge, diagnosis, treatment, and quality of life. Results: A total of 188 online surveys were included in the analysis. Participants represent 20 of 26 states in Brazil and have a mean age of 44. Of the 188 participants, 114 are members of the Network. Knowledge about mBC was assessed through patient self-reporting. Approximately one third of patients (32%) reported little to no knowledge of mBC. When a patient does have questions about their diagnosis and treatment, a majority (83%) seek information from their physician. The Network was also indicated as a resource referenced by patients (51%). To understand the cancer journey, questions focused on diagnosis, treatment, and quality of life. Twenty-two percent (22%) of patients stated the most complicated or longest step of their journey was identifying symptoms of metastasis. The process of diagnosis was challenging, as well. Thirty-six percent (36%) of patients reported their metastasis was an incidental (by chance) diagnosis and 30% had little or insufficient information about the possibility of metastasis. After diagnosis, only 17% of patients continued working, while 78% worked prior to diagnosis. During treatment, the greatest hurdles in the patient journey include a decline in quality of life (42%) and lack of understanding or access to information about mBC (31%). The life of the patient is also impacted after diagnosis and treatment. Sixty-eight percent (68%) of patients expressed fear of the future and 61% felt they could no longer do the activities they previously enjoyed. Conclusion: This research demonstrates the lack of available information specific to a mBC diagnosis and the need for additional support throughout the cancer journey for patients living with mBC. Current breast cancer resources do not adequately address these challenges.

scholarly journals Breast cancer screening in Brazil. Barriers related to the health system

2017 ◽  
Vol 63 (5) ◽  
pp. 466-474 ◽  
Author(s):  
René Aloisio da Costa Vieira ◽  
Alessandro Formenton ◽  
Silvia Regina Bertolini
Keyword(s):  
Breast Cancer ◽  
Cancer Screening ◽  
Health System ◽  
Breast Cancer Screening ◽  
Diagnosis And Treatment ◽  
Stage At Diagnosis ◽  
The Public ◽  
Effective Order ◽  
Study Results

Summary Objective: Identify factors related to the health system that lead to a late diagnosis of breast cancer in Brazil. Method: We performed a systematic review in the PubMed and LILACS databases using as keywords "Breast cancer," "system of health" and "Brazil or Brasil." We evaluated the content of the articles using the PRISMA methodology based on PICTOS. The final date was 12/16/2015. We were able to identify 94 publications in PubMed and 43 publications in LILACS. After assessing the title and summary, and excluding 21 repeated publications, we selected 51 publications for full evaluation. At this stage, we excluded 21 articles, with 30 publications remaining for study. Results: The population coverage is low, and there are problems related to the quality of mammography. Patients with lower income, nonwhite and less educated are more vulnerable. We observed punctual and initial experiences in breast cancer screening. Diagnosis and treatment flows must be improved. The inequality in mortality reflects the differences related to screening structure and treatment. Better results are observed in well-structured services. Conclusion: There are several barriers in the health system leading to advanced stage at diagnosis and limiting the survival outcomes. The establishment of a rapid and effective order for diagnosis and treatment, based on hierarchical flow, are important steps to be improved in the public health context.

Maternal and fetal outcome after breast cancer in pregnancy

1992 ◽  
Vol 39 (3) ◽  
pp. 252-252 ◽  
Author(s):  
D Zemlickis ◽  
M Lishner ◽  
P Degendorfer ◽  
T Panzarella ◽  
B Burke ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Fetal Outcome ◽  
Cancer In Pregnancy ◽  
In Pregnancy

Maternal and fetal outcome after breast cancer in pregnancy

1992 ◽  
Vol 166 (3) ◽  
pp. 781-787 ◽  
Author(s):  
Donna Zemlickis ◽  
Michael Lishner ◽  
Pamela Degendorfer ◽  
Tony Panzarella ◽  
Bonnie Burke ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Fetal Outcome ◽  
Cancer In Pregnancy ◽  
In Pregnancy

scholarly journals Quality of Breast Cancer Diagnosis and Treatment: Audit and Outcome Analysis in North Eastern Cancer Centre of India

2020 ◽  
Vol 7 (17) ◽  
pp. 872-875
Author(s):  
Anuj Sharma Singh ◽  
Ashish Gupta ◽  
Barsha Sarma ◽  
Kanakeshwar Bhuyan ◽  
Bibhash Chandra Goswami
Keyword(s):  
Breast Cancer ◽  
Cancer Diagnosis ◽  
Breast Cancer Diagnosis ◽  
Diagnosis And Treatment ◽  
Outcome Analysis ◽  
Cancer Centre ◽  
North Eastern

Maternal and fetal outcome following breast cancer in pregnancy

1996 ◽  
pp. 95-106 ◽  
Author(s):  
D. Zemlickis ◽  
M. Lishner ◽  
P. Degendorfer ◽  
T. Panzarella ◽  
S. B. Sutcliffe ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Fetal Outcome ◽  
Cancer In Pregnancy ◽  
In Pregnancy

scholarly journals Diagnosis and treatment of breast cancer in pregnancy

2017 ◽  
Vol 15 (2) ◽  
pp. 120-128
Author(s):  
Agnieszka Żyromska ◽  
◽  
Magdalena Adamczak-Sobczak ◽  
Sylwia Szablewska ◽  
◽  
...  
Keyword(s):  
Breast Cancer ◽  
Diagnosis And Treatment ◽  
Cancer In Pregnancy ◽  
In Pregnancy

scholarly journals Impact of the COVID-19 pandemic on breast cancer diagnosis

Mastology ◽  
2020 ◽  
Vol 30 ◽  
Author(s):  
Cícera Chaves Lôbo ◽  
Luiz Gonzaga Porto Pinheiro ◽  
Paulo Henrique Diógenes Vasques
Keyword(s):  
Breast Cancer ◽  
Cancer Diagnosis ◽  
Delayed Diagnosis ◽  
Breast Cancer Diagnosis ◽  
Diagnosis And Treatment ◽  
Control Objective ◽  
Screening Coverage ◽  
Reference Service ◽  
The Impact ◽  
Series Study

Introduction: In 2020, a total of 2,510 new cases of breast cancer were estimated in Ceará State, 14% above the figures of 2019. In the context of the COVID-19 pandemic, postponing screening and assessing the risks and benefits of elective procedures was needed, rescheduled until after their control. Objective: We sought to identify the impact of the COVID-19 pandemic in the care of a Reference Service for Breast Cancer Diagnosis. Methods: Time series study, with analysis of the production of the consultations carried out from March to June of the current year in a service located in Fortaleza City, Ceará State. Results: There was a reduction of up to 84% in the services offered, with emphasis on mammography and ultrasound procedures, with 95 and 100%, respectively. The diagnosis of new cases and the performance of surgeries reduced by up to 60 and 56%, respectively. The months with the greatest impact were April and May, with a progressive resumption in June. Conclusion: The study evaluated a reference service of relevance in the state reality. Considering that many cases are identified during screening, postponing mammograms contributed to a delayed diagnosis. The findings are believed to pose severe consequences, considering the annual increase in the incidence of the disease, the low screening coverage, the high number of cases in advanced staging, the ascending mortality, and the low supply of diagnostic services. Diverting attention exclusively to the pandemic represents a worldwide challenge, but cancer is an important cause of morbidity and mortality, and cannot be neglected. There is concern that delaying screening, diagnosis, and treatment of breast cancer may cost more lives than COVID-19 itself. Post-pandemic requires planning to promote harm reduction resulting from the delay in the diagnosis and treatment of the repressed demand, in a disaggregated and overloaded system.

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