exon amplification
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2009 ◽  
Vol 70 ◽  
pp. S88
Author(s):  
Carly Masaberg ◽  
Kanthi Kariyawasam ◽  
Weiyan Yan ◽  
Vanessa Degrassi ◽  
Shamirah Johnson ◽  
...  


BioTechniques ◽  
2001 ◽  
Vol 30 (3) ◽  
pp. 490-496 ◽  
Author(s):  
Peter Bugert ◽  
Sonja Decker ◽  
Harald Klüter


2000 ◽  
Vol 5 (5) ◽  
pp. 502-509 ◽  
Author(s):  
H Chen ◽  
Y Huo ◽  
S Patel ◽  
X Zhu ◽  
T Swift-Scanlan ◽  
...  




1998 ◽  
Vol 14 (3) ◽  
pp. 177-186 ◽  
Author(s):  
M. Rohrbach ◽  
R. Kraemer ◽  
S. Liechti-Gallati

Background: The gene of the beta subunit of the high affinity receptor for IgE (FcεRI-β) encoded on chromosome 11q13 has recently been identified as a candidate gene for asthma and atopy. Two coding variations, E237G and I181L have been described as being associated with asthma and atopy. Our aim was to investigate a Swiss population of atopic and asthmatic children for variations in this gene.Methods: We screened all 7 exons of the FcεRI-β- gene in 224 atopic/asthmatic, 68 relatives and 159 control subjects using exon amplification by PCR and single strand conformation polymorphism (SSCP) analysis followed by fluorescence based DNA sequencing.Results: The sequence variant E237G was found in 3.7% in atopics and in 2.6% in the control population. None of the samples carried the I181L mutation. In addition, we characterised nine novel mutations (1 nonsense mutation, 2 missense mutations, mutation, 2 silent mutations, 4 intronic mutations).Conclusions: Our results suggest that the E237G does not have a primary effect on the development of atopy and asthma, and thus excludes the FcεRI-β locus from being a candidate gene directly involved in these diseases.



Genomics ◽  
1997 ◽  
Vol 42 (2) ◽  
pp. 364-366 ◽  
Author(s):  
Hideo Orimo ◽  
Masae Goseki-Sone ◽  
Seiji Sato ◽  
Takashi Shimada
Keyword(s):  


1995 ◽  
Vol 57 (2) ◽  
pp. 320-323 ◽  
Author(s):  
T. J. Lerner ◽  
K. L. D'Arigo ◽  
J. L. Haines ◽  
N. A. Doggett ◽  
P. E. M. Taschner ◽  
...  


Genomics ◽  
1995 ◽  
Vol 26 (2) ◽  
pp. 245-253 ◽  
Author(s):  
Kumiko Koyama ◽  
Kazunori Sudo ◽  
Yusuke Nakamura


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