Cross-modal perceptual enhancement of unisensory targets is uni-directional and does not affect temporal expectations

Previous studies demonstrated that redundant target stimuli can enhance performance due to multisensory interplay and interactively facilitate performance enhancements due to temporal expectations (TE; faster and accurate reactions to temporally expected targets). Here we tested whether other types of multisensory interactions – i.e. interactions evoked by temporally flanking irrelevant stimuli – can result in similar performance patterns and boost not only unisensory target perception (multi-vs. unisensory sequences) but also unisensory temporal expectations (expected vs. unexpected). To test our hypothesis, we presented sequences of 12 stimuli (10 Hz) which either consisted of auditory (A), visual (V) or alternating auditory-visual stimuli (e.g. A-V-A-V-…) with either auditory (AV(A)) or visual (AV(V)) targets. Participants had to discriminate target frequency which was unpredictable by temporal regularities (expected vs. unexpected target positions) and by stimulation sequence (A, V, AV(A), AV(V)). Moreover, we ran two experiments in which we presented redundant multisensory targets and manipulated the speed of the stimulation sequence (10 vs. 15 Hz stimulus trains) to control whether the results of Experiment 1 depended on sequence speed. Performance for unisensory targets was affected by temporally flanking distractors, with multisensory interactions selectively improving unisensory visual target perception. Yet, only redundant multisensory targets reliably affected TEs. Together, these results indicate that cross-modal facilitation of unisensory target perception in fast stimulus streams is uni-directional, but also differs from multisensory interactions evoked by redundant targets; more specifically, it appears to be context-dependent (task, design etc.) whether unisensory stimulation (unlike redundant target stimulation) allows for the generation of temporal expectations.

Complementary functions of the mechanosensitive factors egr1, klf2b and klf2a instruct the endocardial program

Mechanical forces are key modulators of valvulogenic developmental programs. However, the mechanosensitive gene network underlying this process remains unclear. It is well established that contractile and flow forces activate endocardial expression of the transcription factor klf2a during valve morphogenesis. We report two novel transcription factors with a function in heart valve formation in zebrafish: egr1 and klf2b. Genome-wide analysis of gene expression reveals that the endocardial transcriptional programs modulated by klf2a, klf2b, and egr1 mainly contain non-redundant targets. Several of these targets have been implicated in endothelial-to-mesenchymal transition (EMT). Many of the deregulated genes exhibit changes in chromatin accessibility pointing to potential direct effects of these factors. Finally, in vivo phenotypic analyses show that VEGF receptor 1 (flt1) is a target of egr1 and klf2b during early valvulogenesis. These findings suggest that klf2a, klf2b, and egr1 cooperate for the activation of EMT program in response to mechanosensitive inputs. We propose that the combinatorial action of these factors mediates flow mechanotransduction to control the endocardial program, especially for valve development.

Coactive Processing of Dimensionally Redundant Targets Within the Auditory Modality?

Previous reaction time studies have demonstrated coactivation processes within the visual modality for redundant stimuli that differ in two dimensions (e.g., shape and color). The present study provides novel results of analogous processes within the auditory modality. A redundant-target effect (RTE) was obtained in a Go/NoGo experiment using tones that differed in location and/or frequency. Participants were asked to respond to a specific tone location (e.g., left) and/or tone frequency (e.g., 200 Hz) of auditory stimuli. For redundant targets (e.g., a 200 Hz tone presented to the left), an RTE was observed which was too large to be explained by mere statistical facilitation. Therefore, responses to redundant targets were triggered by a combined activation of the target dimensions. The results are consistent with the modular hybrid account of Mordkoff and Yantis (1993) .