dextro amphetamine
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2019 ◽  
Vol 30 (4) ◽  
pp. 2358-2371 ◽  
Author(s):  
Rebecca B Hughes ◽  
Jayde Whittingham-Dowd ◽  
Rachel E Simmons ◽  
Steven J Clapcote ◽  
Susan J Broughton ◽  
...  

Abstract 2p16.3 deletions, involving heterozygous NEUREXIN1 (NRXN1) deletion, dramatically increase the risk of developing neurodevelopmental disorders, including autism and schizophrenia. We have little understanding of how NRXN1 heterozygosity increases the risk of developing these disorders, particularly in terms of the impact on brain and neurotransmitter system function and brain network connectivity. Thus, here we characterize cerebral metabolism and functional brain network connectivity in Nrxn1α heterozygous mice (Nrxn1α+/− mice), and assess the impact of ketamine and dextro-amphetamine on cerebral metabolism in these animals. We show that heterozygous Nrxn1α deletion alters cerebral metabolism in neural systems implicated in autism and schizophrenia including the thalamus, mesolimbic system, and select cortical regions. Nrxn1α heterozygosity also reduces the efficiency of functional brain networks, through lost thalamic “rich club” and prefrontal cortex (PFC) hub connectivity and through reduced thalamic-PFC and thalamic “rich club” regional interconnectivity. Subanesthetic ketamine administration normalizes the thalamic hypermetabolism and partially normalizes thalamic disconnectivity present in Nrxn1α+/− mice, while cerebral metabolic responses to dextro-amphetamine are unaltered. The data provide new insight into the systems-level impact of heterozygous Nrxn1α deletion and how this increases the risk of developing neurodevelopmental disorders. The data also suggest that the thalamic dysfunction induced by heterozygous Nrxn1α deletion may be NMDA receptor-dependent.



Author(s):  
Eran Harary ◽  
David Siner ◽  
Hanna Ron ◽  
Jonathan S. Rubin ◽  
Yaron Daniely




2009 ◽  
Vol 27 (8) ◽  
pp. 933-934 ◽  
Author(s):  
Frank LoVecchio ◽  
John Ozimek ◽  
Belinda Sawyers ◽  
Dan Thole
Keyword(s):  


2008 ◽  
Vol 61 (4) ◽  
pp. 351-359 ◽  
Author(s):  
Brent M. McGrath ◽  
Ryan McKay ◽  
Sanjay Dave ◽  
Peter Seres ◽  
Aalim M. Weljie ◽  
...  


2004 ◽  
Vol 5 (1) ◽  
pp. 38-44 ◽  
Author(s):  
Peter H Silverstone ◽  
Sheila J Asghar ◽  
Tina O'donnell ◽  
Michele Ulrich ◽  
Christopher C Hanstock


2003 ◽  
Vol 13 ◽  
pp. S175
Author(s):  
P. Silverstone ◽  
M. Wilson ◽  
A. Wilman


2002 ◽  
Vol 17 (8) ◽  
pp. 425-429 ◽  
Author(s):  
Peter H. Silverstone ◽  
Tina O'Donnell ◽  
Michele Ulrich ◽  
Sheila Asghar ◽  
Christopher C. Hanstock
Keyword(s):  


1993 ◽  
Vol 16 (6) ◽  
pp. 1235-1239 ◽  
Author(s):  
ARMANDO SUSMANO ◽  
ANNABELLE S. VOLGMAN ◽  
THOMAS A. BUCKINGHAM


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