A Single Firm Nodule of the Upper Lip: A Case Report

Canalicular Adenoma (CA) is a benign accessory salivary gland neoplasm. It represents less than 1% of salivary gland tumors. It occurs generally on the upper lips in female patients over 50 years of age. We report a case of canalicular adenoma that arose from buccal minor salivary glands of the upper lip without any symptomatology. Clinically, CA appears as an often single firm mass of 1cm, sparing the main salivary glands which is not pathognomonic of canalicular adenoma. Treatment of choice is enucleation to rule out many differential diagnoses that may present clinically as an asymptomatic nodule. Recurrences are rare. Histological features are characteristic and usually allow a definitive diagnosis to be made with confidence. However, many differential diagnoses remain to be ruled out.

Effects of Glucan Supplementation on Aged Hematopoietic Progenitor Cells

Age related changes in activity of hematopoietic progenitor cells led us to investigate the possibility that glucan supplementation might overcome this suppression. In our study, we focused on differences of these cells in young (8 weeks old) and old (18 months old) mice after supplementation of yeast-derived insoluble glucan. Our results showed significant differences in reconstitution ability of progenitor cells as well as changes in level of stromal cell-derived factor 1α between young and old mice exist and can be partly restored by glucan supplementation.

Ductal Carcinoma In situ with Focal Invasion Arising in Fibroadenoma: A Case Report and Review of Literature

Fibroadenoma is the most commonly diagnosed benign tumor of the breast with highest occurrence in adolescent and young women. Its coexistence with invasive ductal carcinoma is extremely rare and infrequently reported. We report a case of 30-year-old female who was diagnosed with extensive ductal carcinoma in situ with focal invasion within fibroadenoma on lumpectomy. The carcinoma was detected incidentally on histopathological examination. Therefore a careful and extensive sampling of the tissue is required to prevent a false negative diagnosis by pathologists.