ACS Pharmacology & Translational Science
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scholarly journals In Silico and Ex Vivo Analyses of the Inhibitory Action of the Alzheimer Drug Posiphen and Primary Metabolites with Human Acetyl- and Butyrylcholinesterase Enzymes

2022 ◽  
Author(s):  
Sidra Batool ◽  
Tiyyaba Furqan ◽  
Muhammad Sibte Hasan Mahmood ◽  
David Tweedie ◽  
Mohammad A. Kamal ◽  
...  
Keyword(s):  
In Silico ◽  
Inhibitory Action ◽  
Ex Vivo ◽  
Primary Metabolites

Structure-Based Design and Biological Evaluation of Novel Caspase-2 Inhibitors Based on the Peptide AcVDVAD-CHO and the Caspase-2-Mediated Tau Cleavage Sequence YKPVD314

2022 ◽  
Author(s):  
Merlin Bresinsky ◽  
Jessica M. Strasser ◽  
Bernadette Vallaster ◽  
Peng Liu ◽  
William M. McCue ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Caspase 2 ◽  
Tau Cleavage

scholarly journals SARS-CoV-2 Nucleocapsid Protein TR-FRET Assay Amenable to High Throughput Screening

2022 ◽  
Author(s):  
Kirill Gorshkov ◽  
Desarey Morales Vasquez ◽  
Kevin Chiem ◽  
Chengjin Ye ◽  
Bruce Nguyen Tran ◽  
...  
Keyword(s):  
High Throughput ◽  
Nucleocapsid Protein ◽  
High Throughput Screening

In Vivo Pharmacodynamic Method to Assess Complement C5a Receptor Antagonist Efficacy

2021 ◽  
Author(s):  
Cedric S. Cui ◽  
Vinod Kumar ◽  
Declan M. Gorman ◽  
Richard J. Clark ◽  
John D. Lee ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
C5a Receptor ◽  
Complement C5a
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