Structure-Based Design and Biological Evaluation of Novel Caspase-2 Inhibitors Based on the Peptide AcVDVAD-CHO and the Caspase-2-Mediated Tau Cleavage Sequence YKPVD314

2022 ◽  
Author(s):  
Merlin Bresinsky ◽  
Jessica M. Strasser ◽  
Bernadette Vallaster ◽  
Peng Liu ◽  
William M. McCue ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Caspase 2 ◽  
Tau Cleavage

Chemical and biological evaluation of native bamboo species from atlantic rain forest

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
MT Grombone-Guaratini ◽  
LM Brandão Torres ◽  
DA Faria ◽  
CM José
Keyword(s):  
Rain Forest ◽  
Biological Evaluation ◽  
Atlantic Rain Forest ◽  
Bamboo Species

Synthesis and Biological Evaluation of New Salvinorin B-Sulfonate Ester Ligands to Opioid Receptors

Planta Medica ◽  
2013 ◽  
Vol 79 (05) ◽  
Author(s):  
PR Polepally ◽  
BL Roth ◽  
K White ◽  
E Vardy ◽  
JK Zjawiony
Keyword(s):  
Opioid Receptors ◽  
Biological Evaluation ◽  
Sulfonate Ester ◽  
Synthesis And Biological Evaluation

SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF SOME 2-ARYLBENZOXAZOLE ACETIC ACID DERIVATIVES AS PROMISING ANTICANCER AGENTS

2020 ◽  
Vol 77 (5) ◽  
pp. 717-723
Author(s):  
Qais Abualassal ◽  
Jamal Jilani ◽  
Areej Assaf ◽  
Reham Abu shmies
Keyword(s):  
Acetic Acid ◽  
Anticancer Agents ◽  
Biological Evaluation

SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF 3-FORMYL INDOLE BASED SCHIFF BASES

2018 ◽  
Vol 7 (6) ◽  
Author(s):  
Singh Gurvinder ◽  
Singh Prabhsimran ◽  
Dhawan R. K.
Keyword(s):  
Antimicrobial Activity ◽  
Spectral Analysis ◽  
Schiff Bases ◽  
Antimicrobial Agents ◽  
Biological Evaluation ◽  
Fungal Strain ◽  
Bacterial Strains ◽  
Standard Drug ◽  
Gram Negative ◽  
E Coli

In order to develop new antimicrobial agents, a series of 3-formyl indole based Schiff bases were synthesized by reacting 3-formyl indole(indole-3-carboxaldehyde) with substituted aniline taking ethanol as solvent. The reaction was carried in the presence of small amount of p-toluene sulphonic acid as catalyst.All the synthesized compounds were characterized by IR, 1H-NMR spectral analysis. All the synthesized compounds were evaluated for antimicrobial activity against two gram positive bacterial strains (B. subtilisand S. aureus) and two gram negative bacterial strains (P. aeruginosaand E. coli) and one fungal strain (C. albicans). All the synthesized compounds were found to have moderate to good antimicrobial activity. The  standard drug amoxicillin, fluconazole were used for antimicrobial activity. Among the synthesized compounds, the maximum antimicrobial activity was shown by compounds GS04, GS07, GS08 and GS10.

Sign in / Sign up

Export Citation Format

Share Document