Immunofluorescence of cutaneous vasculitis associated with systemic disease

1971 ◽  
Vol 104 (3) ◽  
pp. 254-259 ◽  
Author(s):  
A. L. Schroeter
Keyword(s):  
Systemic Disease ◽  
Cutaneous Vasculitis

scholarly journals Varied presentations of cutaneous vasculitis: a case series

2020 ◽  
Vol 8 (8) ◽  
pp. 3066
Author(s):  
Pinky Gupta ◽  
Shweta Ganorkar ◽  
Surekha Bhalekar ◽  
Rajiv Rao
Keyword(s):  
Blood Vessels ◽  
Histopathological Examination ◽  
Wide Spectrum ◽  
Systemic Disease ◽  
Case Series ◽  
Clinical Severity ◽  
Cutaneous Vasculitis ◽  
Venous Stasis ◽  
Duration Of Symptoms ◽  
Organ Systems

Vasculitis involves a wide spectrum of clinicopathological process with reactive damage to the involved blood vessels. There is loss of vessel integrity instigating haemorrhage & luminal compromise leading to ischemia and necrosis of the tissue supplied by the involved vessels. It may affect varied size and type of blood vessels at different locations. It may be primary or secondary to systemic disease. It may involve a single organ like skin or may involve different organ systems at the same time. This case series include six cases of cutaneous vasculitis affecting different organs with varied presentations. Skin biopsies of six patients with unusual presentations were studied. Their complete history, physical examinations, laboratory investigations including serology were analysed and correlated with histopathological findings. The patients presented with different duration of symptoms varying from as short as 15 days to 1 year. Skin lesions were present in all cases while cardiac manifestation was seen in one. Serology and autoimmune disease markers were negative in all cases except one. However, histopathological features were in concordance with the clinical diagnosis of vasculitis. They were further classified as vasculitis secondary to Churg Strauss syndrome, venous stasis, Henoch Schonlein purpura or leucocytoclastic vasculitis.Vasculitis though a rare disease may manifest as an acute or chronic condition. It needs timely diagnosis by histopathological examination to aid in further management. It is important to assess the clinical severity in primary and secondary vasculitis, as it determines morbidity and mortality.

Cutaneous vasculitis, connective tissue diseases, and urticaria

2010 ◽  
pp. 4626-4655
Author(s):  
Susan Burge ◽  
Graham S. Ogg
Keyword(s):  
Connective Tissue ◽  
Blood Vessels ◽  
Systemic Vasculitis ◽  
Vascular Inflammation ◽  
Systemic Disease ◽  
Connective Tissue Diseases ◽  
Vascular Occlusion ◽  
Clinical Findings ◽  
Cutaneous Vasculitis ◽  
Imaging Studies

Vasculitis (angiitis) denotes necrotizing inflammation of the blood vessels; occlusive vasculopathy implies vascular occlusion without significant vascular inflammation. A small-vessel cutaneous vasculitis is the most common vasculitis affecting the skin, and may be the first sign of a systemic vasculitis, but 50% of patients have no systemic disease. The clinical findings must be integrated with the results of serological, pathological, and imaging studies to reach a diagnosis....

Cutaneous vasculitis, connective tissue diseases, and urticaria

2020 ◽  
pp. 5639-5676
Author(s):  
Volha Shpadaruk ◽  
Karen E. Harman
Keyword(s):  
Connective Tissue ◽  
Lupus Erythematosus ◽  
Systemic Vasculitis ◽  
Systemic Disease ◽  
Subcutaneous Fat ◽  
Connective Tissue Diseases ◽  
Vascular Occlusion ◽  
Cutaneous Vasculitis ◽  
American College Of Rheumatology ◽  
Cutaneous Problem

Vasculitis (angiitis) denotes necrotizing inflammation of the blood vessels; occlusive vasculopathy implies vascular occlusion without significant vascular inflammation. A small-vessel cutaneous vasculitis is the most common vasculitis affecting the skin, and may be the first sign of a systemic vasculitis, but 50% of patients have no systemic disease. Systemic lupus erythematosus is diagnosed if four or more of the American College of Rheumatology revised criteria for the classification of this disease are present, either sequentially or simultaneously. Meanwhile, dermatomyositis is an uncommon multisystem autoimmune disease in which inflammatory skin changes are associated with polymyositis of skeletal muscle. Scleroderma means thickened, fibrotic, bound-down skin. It might develop in association with a systemic connective tissue disease (systemic sclerosis) or present as a localized cutaneous problem. Panniculitis is inflammation of the subcutaneous fat, sometimes associated with vasculitis. It presents with erythematous subcutaneous nodules, most often on the lower leg.

scholarly journals Clinicopathological Study on Cutaneous Vasculitis

2021 ◽  
Vol 16 (1) ◽  
pp. 61-64
Author(s):  
Md Shajahan Siraj ◽  
Mohammad Maksudur Rahman ◽  
ATM Rezaul Karim ◽  
Md Abdul Wahab
Keyword(s):  
Leukocytoclastic Vasculitis ◽  
Systemic Disease ◽  
Cross Sectional Study ◽  
Cutaneous Vasculitis ◽  
Antineutrophil Cytoplasmic Antibodies ◽  
Cross Sectional ◽  
Small Vessels ◽  
Laboratory Investigations ◽  
Nodular Vasculitis ◽  
Schonlein Purpura

Introduction: Cutaneous vasculitis is an inflammatory process directed primarily at vessels which results in the destruction of the vessel walls leading to hemorrhage, ischemia, and/or infarction. Cutaneous involvement in cutaneous vasculitis may be primary or reflector of a systemic disease. Aim: To find out the aetiology and clinicopathologic features of cutaneous vasculitis in Chattogram costal area. Methods: A total of 50 patients diagnosed clinically and confirmed histologically as cutaneous vasculitis were selected for this descriptive cross-sectional study from March 2016 to August 2017. Detailed history, clinical examination and the baseline investigations along with special tests such as Antinuclear antibodies (ANA) profile, Antineutrophil Cytoplasmic Antibodies (ANCA) and Antistreptolysin O (ASO) titer were conducted in all patients. Results: Out of 50 cases, 20% of the patients had (Henoch-Schonlein purpura) HSP and 10% had Urticarial vasculitis (UV), collagen vascular disease associated vasculitis were present in 2%, Cutaneous polyarteritisnodosa (C-PAN), eosinophilic vasculitis and nodular vasculitis were present in 4% of the patients each. Rests of the patients (54%) were designated as idiopathic cutaneous small vessels vasculitis (SVV). The commonest lesion was palpable purpura. Infection was the commonest cause of cutaneous vasculitis for about 22%, followed by drugs (20%), malignancy (2%) and connective tissue disease (2%). Two patients with HSP had positive ANCA, 3 without any overt manifestations and 1 with systemic sclerosis. Histologically Leukocytoclastic vasculitis (LCV) was the commonnest pattern (72%), lymphocytic in 20%, granulomatous in 4% and eosinophilic vasculitis in 4% of patients. Conclusion: Cutaneous SVV is the commonest form of vasculitis. The heterogenecity of this group of disorders is well represented in this study. To reach an etiological diagnosis of vasculitis, clinical and pathological features need to be correlated and supplemented by laboratory investigations. JAFMC Bangladesh. Vol 15, No 1 (June) 2020: 61-64

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