Cutaneous reactions to granulocyte-monocyte colony-stimulating factor

1992 ◽  
Vol 128 (8) ◽  
pp. 1055-1059 ◽  
Author(s):  
D. R. Mehregan
Keyword(s):  
Colony Stimulating Factor ◽  
Cutaneous Reactions ◽  
Stimulating Factor

scholarly journals Messenger RNA expression of the cytokine gene cluster, interleukin 3 (IL-3), IL-4, IL-5, and granulocyte/macrophage colony-stimulating factor, in allergen-induced late-phase cutaneous reactions in atopic subjects.

1991 ◽  
Vol 173 (3) ◽  
pp. 775-778 ◽  
Author(s):  
A B Kay ◽  
S Ying ◽  
V Varney ◽  
M Gaga ◽  
S R Durham ◽  
...  
Keyword(s):  
Gene Cluster ◽  
Messenger Rna ◽  
Late Phase ◽  
Colony Stimulating Factor ◽  
Interleukin 3 ◽  
Gm Csf ◽  
Cutaneous Reactions ◽  
Macrophage Colony Stimulating Factor ◽  
Macrophage Colony ◽  
Stimulating Factor

Cryostat sections from skin biopsies from 24-h allergen-induced late-phase cutaneous reactions (LPR) in 14 human atopic subjects were hybridized with 35S-labeled RNA probes for a number of cytokines. mRNA was detected for interleukin 3 (IL-3) (8/14), IL-4 (10/14), IL-5 (11/14), and granulocyte/macrophage colony-stimulating factor (GM-CSF) (13/14). Only 5 of 14 gave hybridization signals for IL-2, and 0 of 14 for interferon gamma. Biopsies from diluent controls gave only occasional weak signals. These results suggest that cells infiltrating the site of the 24-h LPR transcribe mRNA for the IL-3, IL-4, IL-5, and GM-CSF gene cluster and support the hypothesis that atopy is associated with preferential activation of cells having a similar cytokine profile to the murine T helper type 2 subset.

HISTOPATHOLOGY OF CUTANEOUS REACTIONS TO GRANULOCYTE COLONY-STIMULATING FACTOR.

1998 ◽  
Vol 20 (6) ◽  
pp. 588
Author(s):  
M C. Fariña ◽  
M L. Soriano ◽  
R. Grilli ◽  
M J. Izquierdo ◽  
P. Escalonilla ◽  
...  
Keyword(s):  
Granulocyte Colony Stimulating Factor ◽  
Colony Stimulating Factor ◽  
Cutaneous Reactions ◽  
Stimulating Factor
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