The Sicca Syndrome (Sjögren's Syndrome)

1960 ◽  
Vol 105 (6) ◽  
pp. 849 ◽  
Author(s):  
CHARLES W. DENKO
Keyword(s):  
Sjögren’S Syndrome ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Sicca Syndrome ◽  
Sjögren‘S Syndrome

scholarly journals Discrimination between Sjögren's and Non-Sjögren's Sicca Syndrome by Sialoscintigraphy and Antibodies against α-Fodrin and Ro/La Autoantigens

2009 ◽  
Vol 37 (4) ◽  
pp. 1088-1096 ◽  
Author(s):  
K-S Chen ◽  
M-C Jiang ◽  
C-J Li ◽  
O-K Liu ◽  
C-SS Tsai
Keyword(s):  
Salivary Gland ◽  
Sjögren’S Syndrome ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Sicca Syndrome ◽  
Dry Eyes ◽  
Sicca Symptoms ◽  
Grade Iii ◽  
Sjögren‘S Syndrome

Both Sjögren's syndrome (SS) and non-Sjögren's syndrome (NSS) can present with the sicca symptoms of dry eyes and a dry mouth but they are distinct pathological entities that require diagnostic discrimination. This study included 82 sicca syndrome patients and examined the ability of sialoscintigraphy and antibodies against the autoantigens α-fodrin, Ro and La to discriminate between SS and NSS. A total of 30.8% of SS patients compared with 58.8% of NSS patients were α-fodrin positive. The prevalence of Ro positivity was 69.4% for SS patients compared with 0% for NSS patients. The prevalence of La positivity was 52.4% for SS compared with 0% for NSS patients. Sialoscintigraphy showed that more NSS patients had grade III salivary gland impairment compared with SS patients (64.7% versus 19.4%). These data suggest that using sialoscintigraphy in combination with measuring the levels of serum α-fodrin, Ro and La might be useful for SS and NSS discrimination.

scholarly journals Sjögren’s Syndrome: Concerted Triggering of Sicca Conditions

2019 ◽  
Vol 2019 ◽  
pp. 1-11 ◽  
Author(s):  
Zygmunt Mackiewicz ◽  
Justyna Mażul ◽  
Ieva Narkevičiūtė ◽  
Irena Dumalakienė ◽  
Irena Butrimienė ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Salivary Glands ◽  
Sjögren’S Syndrome ◽  
Sjögren's Syndrome ◽  
Study Groups ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Mumps Virus ◽  
Sicca Syndrome ◽  
Sjögren‘S Syndrome

Aim. The aim of this study was to evaluate the expression of persistence of mumps virus and some cells that interact with viral infection in the focus of the autoimmune epithelitis and peripheral blood of Sjögren’s syndrome patients in comparison to patients with rheumatoid arthritis (RA) and nonautoimmune sicca syndrome (nSS). Materials and Methods. 126 patients (119 women and 7 men) were grouped into four groups: (1) patients with primary Sjögren’s syndrome (pSS), (2) patients with secondary Sjögren’s syndrome due to rheumatoid arthritis (sSS), (3) patients with rheumatoid arthritis (RA), and (4) patients with nonautoimmune sicca syndrome (nSS). Immunohistochemical analysis of immune response to the suggested silent persistence of mumps virus in the minor labial salivary gland biopsies and flow cytometric analysis of blood cells was done. Results. Immunohistochemical signs of mumps virus persistence were found in the minor salivary glands of all study groups. Also, a significantly different immune response to virus infection (protein IFI16, interferons gamma and beta, dendritic cells, and receptor for natural killers) was revealed in the minor salivary glands of the study groups. Cytometric analysis of the blood cells revealed a dropping amount of circulating natural killers and dendritic cells in patients with SS. Significant correlations between immunohistochemical staining and serological findings were revealed. Conclusions. Abundant immunohistochemical signs of mumps virus protein in the salivary glands and depletion of circulating immune cells make a background for thought of presumable mumps or/and other virus participation in epithelial damage causing sicca syndrome in predisposed patients.

Expression of Proteasomal Immunosubunit ß1i Is Dysregulated in Inflammatory Infiltrates of Minor Salivary Glands in Sjögren’s Syndrome

2009 ◽  
Vol 36 (12) ◽  
pp. 2694-2703 ◽  
Author(s):  
LARS MORAWIETZ ◽  
LORENA MARTINEZ-GAMBOA ◽  
SONJA SCHEFFLER ◽  
GERT HAUSDORF ◽  
ANJA DANKOF ◽  
...  
Keyword(s):  
Salivary Glands ◽  
Sjögren’S Syndrome ◽  
Sjögren's Syndrome ◽  
Minor Salivary Gland ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Sicca Syndrome ◽  
Minor Salivary Glands ◽  
Inflammatory Infiltrates ◽  
Sjögren‘S Syndrome

Objective.Minor salivary gland specimens were analyzed to investigate dysregulation of the proteasome system in patients with Sjögren’s syndrome (SS) and patients with sicca syndrome.Methods.Labial biopsy specimens from 17 patients with SS and 11 patients with non-autoimmunesicca syndrome were analyzed by immunohistochemistry for expression of the inducible proteasomal subunits ß1i, ß2i, and ß5i. The infiltrating subsets of lymphocytes were characterized using immunofluorescence stainings against the cell-surface markers CD20 and CD27. Two-dimensional electrophoresis and immunoblotting were used for detection of the proteasomal subunits ß1 and ß1i in peripheral blood monocyte cells. Gene expression of the constitutive subunits ß1, ß2, and ß5 and the corresponding inducible subunits ß1i, ß2i, and ß5i was further investigated at the mRNA level in small lip biopsies using real-time polymerase chain reaction.Results.The expression of ß1i in infiltrating and peripheral immune cells was altered in patients with SS compared to patients with non-autoimmune sicca syndrome and healthy controls. No significant differences were found in ß2i and ß5i expression between the same groups in small lip biopsies. Chisholm-Mason grade and ß1i expression were found to be inversely correlated (Spearman r = −0.461, p = 0.014). The phenotype and distribution of the lymphocytic infiltrate showed no differences between patients with primary and secondary SS regardless of ß1i expression.Conclusion.The proteasomal ß1i subunit is dysregulated in peripheral white blood cells and in inflammatory infiltrates of minor salivary glands in patients with SS.

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