Cytogenetic Studies in Blastic Crisis of Chronic Myelocytic Leukemia

Abstract Serial cytogenetic studies were performed on 179 chronic myelocytic leukemia patients (CML) at the Clinical Center of the National Institutes of Health. Patients were divided into 6 groups according to cytogenetic findings: Ph1 negative (18 patients), Ph1 negative with other chromosomal abnormalities (3 patients), Ph1 positive (116 patients), Ph1 positive and negative (10 patients), Ph1 positive with other chromosomal abnormalities (24 patients), and Ph1 positive which turned to other chromosomal abnormalities (8 patients). Patients who were Ph1 negative and negative with other chromosomal abnormalities (11.8 per cent of total) had the shortest median survival, 12 to 15 months. In contrast, the median survival of patients in the Ph1 positive groups was 31 to 40 months. The development of other chromosomal abnormalities in Ph1 positive patients presaged the terminal stage of the disease.

Download Full-text

Transplantation of allogeneic peripheral blood stem cells after myeloablative treatment of a patient in blastic crisis of chronic myelocytic leukemia

American Journal of Hematology ◽

10.1002/ajh.2830470110 ◽

1994 ◽

Vol 47 (1) ◽

pp. 45-49 ◽

Cited By ~ 15

Author(s):

Atsuko Sasaki ◽

Machiko Tsukaguchi ◽

Manabu Hirai ◽

Hidehiro Ohira ◽

Yoshitaka Nakao ◽

...

Keyword(s):

Stem Cells ◽

Peripheral Blood ◽

Chronic Myelocytic Leukemia ◽

Blastic Crisis ◽

Peripheral Blood Stem Cells ◽

Myelocytic Leukemia ◽

Blood Stem Cells

Download Full-text

Additional Philadelphia chromosomes in acute blastic crisis of chronic myelocytic leukemia: possible mechanism of producing additional chromosomal abnormalities

The American Journal of the Medical Sciences ◽

10.1097/00000441-197404000-00004 ◽

1974 ◽

Vol 267 (4) ◽

pp. 229-240 ◽

Cited By ~ 8

Author(s):

KONG-OO GOH

Keyword(s):

Chromosomal Abnormalities ◽

Chronic Myelocytic Leukemia ◽

Blastic Crisis ◽

Myelocytic Leukemia ◽

Additional Chromosomal Abnormalities

Download Full-text

Emergence of a cell line with extreme hypodiploidy in blast crisis of chronic myelocytic leukemia

Blood ◽

10.1182/blood.v53.4.707.707 ◽

1979 ◽

Vol 53 (4) ◽

pp. 707-711 ◽

Cited By ~ 25

Author(s):

RM Como ◽

PR Graze

Keyword(s):

Cell Line ◽

Blast Crisis ◽

Chronic Myelocytic Leukemia ◽

Banding Patterns ◽

Myelocytic Leukemia ◽

Modal Chromosome Number ◽

Response To Chemotherapy ◽

Cytogenetic Studies ◽

A Cell ◽

Complex Chromosome

Abstract Cytogenetic studies in a patient with chronic myelocytic leukemia (CML) demonstrated the emergence of an extremely hypodiploid cell line at the time of blast crisis, a modal chromosome number of 35, with the modal karyotype 35,XY, -3, -4, -5, -7, -9, -11, -12, -13, -15, -16, -17, -19, -20, -22, + t(9;22) (q34;q11, + Mar1, + Mar2, + Mar3. Giemsa-banding confirmed complex chromosome rearrangements and demonstrated distinct banding patterns for the marker chromosomes. Cytologic characteristics of the leukemia blasts were predominantly myeloid. There was no important clinical response to chemotherapy, including vincristine and prednisone, or to radiotherapy.

Download Full-text