scholarly journals Association Between Severe Cerebral Amyloid Angiopathy and Cerebrovascular Lesions in Alzheimer Disease Is Not a Spurious One Attributable to Apolipoprotein E4

2000 ◽  
Vol 57 (6) ◽  
pp. 869 ◽  
Author(s):  
John M. Olichney ◽  
Lawrence A. Hansen ◽  
C. Richard Hofstetter ◽  
Jae-Hong Lee ◽  
Robert Katzman ◽  
...  
2019 ◽  
Vol 79 (7) ◽  
pp. 716-737 ◽  
Author(s):  
María Carmona‐Iragui ◽  
Laura Videla ◽  
Alberto Lleó ◽  
Juan Fortea

2012 ◽  
Vol 71 (8) ◽  
pp. 750-759 ◽  
Author(s):  
Akihiko Hoshi ◽  
Teiji Yamamoto ◽  
Keiko Shimizu ◽  
Yoshikazu Ugawa ◽  
Masatoyo Nishizawa ◽  
...  

2016 ◽  
Vol 12 ◽  
pp. P680-P680
Author(s):  
Janka Hegedus ◽  
Ana Alvarez-Veronesi ◽  
Angela Zwiers ◽  
Anna Charlton ◽  
Ramnik Sekhon ◽  
...  

Stroke ◽  
2021 ◽  
Author(s):  
Lukas Sveikata ◽  
Andreas Charidimou ◽  
Anand Viswanathan

We review the implications of the recently approved aducanumab amyloid-β immunotherapy for treating Alzheimer disease with comorbid cerebral amyloid angiopathy. In clinical trials, amyloid-β immunotherapy has been associated with a high rate of amyloid-related imaging abnormalities, potentially driven by coexisting cerebral amyloid angiopathy. Therefore, immunotherapy’s efficacy in patients may be modified by coexisting cerebrovascular pathology. We discuss the contributions of cerebral amyloid angiopathy on the development of amyloid-related imaging abnormalities and propose strategies to identify cerebral amyloid angiopathy in patients considered for immunotherapy.


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