DANGERS OF DIAGNOSTIC LUMBAR PUNCTURE IN INCREASED INTRACRANIAL PRESSURE DUE TO TUMOR OF THE BRAIN

1929 ◽  
Vol 21 (5) ◽  
pp. 1141 ◽  
Author(s):  
CLEMENT B. MASSON
Keyword(s):  
Intracranial Pressure ◽  
Lumbar Puncture ◽  
Increased Intracranial Pressure ◽  
Diagnostic Lumbar Puncture ◽  
The Brain

scholarly journals Evaluation of cerebrovascular hemodynamics in patients with idiopathic intracranial hypertension using transcranial Doppler

2020 ◽  
Vol 56 (1) ◽  
Author(s):  
Mahmoud M. Allam ◽  
Hatem A. Almasry ◽  
Sandra M. Ahmed ◽  
Youssuf G. Taha ◽  
Mohammed I. Oraby
Keyword(s):  
Intracranial Pressure ◽  
Intracranial Hypertension ◽  
Lumbar Puncture ◽  
Transcranial Doppler ◽  
Idiopathic Intracranial Hypertension ◽  
Pulsatility Index ◽  
Research Work ◽  
Increased Intracranial Pressure ◽  
Significant Relation ◽  
Before And After

Abstract Background Idiopathic intracranial hypertension (IIH) is a disorder of increased intracranial pressure without a clear cause and can have serious visual effects. Previous research work suggests that transcranial Doppler measurements of pulsatility index correlate accurately with elevated intracranial pressure. Objective To assess the cerebrovascular hemodynamic changes in patients with IIH using transcranial Doppler before and after lumbar puncture and CSF withdrawal. Methods An interventional study conducted on 40 patients (31 females and 9 males) fulfilling the modified Dandy criteria for diagnosis of idiopathic intracranial hypertension, MRI brain, and MRV was done to the patients. Lumbar puncture was done for all included patients to measure intracranial pressure and CSF withdrawal. Transcranial Doppler was performed for all included before and after lumbar puncture and CSF withdrawal and the following parameters were measured: peak systolic velocity (PSV), end diastolic velocity (EDV), resistivity index (RI), and pulsatility index (PI). Results Significant relation was found between grades of papilledema and PSV, RI, and PI (p value 0.012, 0.025, 0.016) but no significant relation was found between grades of papilledema and EDV (0.102). Significant changes occurred in parameters of TCD pre- and post-CSF withdrawal including PSV, EDV, and PI (p value 0.001, 0.015, 0.019) denoting a significant change in cerebral hemodynamics after CSF withdrawal which denotes a decrease in intracranial pressure. Conclusion Increased intracranial pressure significantly affects cerebral blood flow. A normalization of transcranial Doppler parameters occurs following lowering of intracranial pressure through lumbar puncture and CSF withdrawal.

Lumbar Puncture Opening Pressure in Patients with Spinal Muscular Atrophy

2021 ◽  
Author(s):  
Lena-Luise Becker ◽  
Claudia Weiß ◽  
Anna Tietze ◽  
Viktoria Martiny ◽  
Angela M. Kaindl
Keyword(s):  
Intracranial Pressure ◽  
Spinal Muscular Atrophy ◽  
Lumbar Puncture ◽  
Clinical Data ◽  
Side Effect ◽  
Treatment Initiation ◽  
Muscular Atrophy ◽  
Underlying Disease ◽  
Increased Intracranial Pressure ◽  
Opening Pressure

AbstractThe announcement of a hydrocephalus as a possible side effect in patients with spinal muscular atrophy (SMA) receiving the drug nusinersen, promoted major concern and warrants further evaluation. In this retrospective monocentric study, we analyzed clinical data, lumbar puncture opening pressure (LOP) measurement, and ophthalmologic and neuroimaging results in 34 patients with SMA types 1 to 3 undergoing treatment with nusinersen. None of the patients reported symptoms indicative of increased intracranial pressure. In our cohort, the LOP was >20 cm H2O in 25 patients (70.5%), and within this group ≥28 cm H2O in 12 patients (35.3%), in two patients, it was increased prior to treatment initiation. Signs of increased intracranial pressure in ophthalmological assessments or brain imaging were only seen in one patient. We did not identify a correlation between increased LOP and SMA type, scoliosis, or age of the patients; however, it was slightly higher in patients receiving sedation. Our results raise the question whether the LOP is generally increased in SMA as part of the underlying disease, if so, what the etiology is, and whether the increased LOP needs to be treated.

scholarly journals SURVIVAL OF POLIOMYELITIC VIRUS IN THE BRAIN OF THE RABBIT

1918 ◽  
Vol 27 (3) ◽  
pp. 443-447 ◽  
Author(s):  
Harold L. Amoss
Keyword(s):  
Intracranial Pressure ◽  
Pressure Effects ◽  
Rabbit Brain ◽  
High Dilution ◽  
Increased Intracranial Pressure ◽  
Intracerebral Inoculation ◽  
Pathological Lesions ◽  
Active Virus ◽  
The Brain

Suspensions of the central nervous tissues of monkeys, containing the active filterable virus of poliomyelitis, may be injected into the brain of rabbits without setting up symptoms, provided the volume of injection does not cause dangerous increased intracranial pressure. Aside from the pressure effects which develop quickly, no other symptoms or pathological lesions are produced by the suspensions. The active virus of poliomyelitis survives in the brain of rabbits for 4 days, as determined by tests in the monkey, into which the excised site of injection in the rabbit brain is reinoculated. It cannot be detected by this test after the expiration of 7 days. The virus of poliomyelitis is unadapted to the rabbit, and neither induces lesions nor survives long in the central nervous organs of that animal. In this respect it differs from certain streptococci cultivated from poliomyelitic tissues. A monkey immunized to streptococcus cultivated from human poliomyelitic nervous tissues yielded a serum which agglutinated the streptococcus in high dilution, but was without neutralizing action on the filtered virus; and the streptococcus-immune monkey was not protected against the effects of an intracerebral inoculation of the filtered virus. The experiments recorded provide additional reasons for concluding that the streptococcus cultivated from cases of poliomyelitis differs essentially from the filterable virus and is not the microbic cause of epidemic poliomyelitis.

Multiple small cavernous angiomas of the brain with increased intracranial pressure

1978 ◽  
Vol 4 (4) ◽  
pp. 376-378 ◽  
Author(s):  
Richard S. A. Tindall ◽  
Joel B. Kirkpatrick ◽  
Fred Sklar
Keyword(s):  
Intracranial Pressure ◽  
Increased Intracranial Pressure ◽  
Cavernous Angiomas ◽  
The Brain

scholarly journals Central neurocytomas of uncommon locations: report of two cases

2006 ◽  
Vol 64 (4) ◽  
pp. 1015-1018 ◽  
Author(s):  
Francinaldo Lobato Gomes ◽  
Luciano Ricardo França ◽  
Samuel Tau Zymberg ◽  
Sérgio Cavalheiro
Keyword(s):  
Differential Diagnosis ◽  
Intracranial Pressure ◽  
Obstructive Hydrocephalus ◽  
Signs And Symptoms ◽  
Pineal Region ◽  
Additional Treatment ◽  
Third Ventriculostomy ◽  
Increased Intracranial Pressure ◽  
The Brain ◽  
Uncommon Location

We report two patients with central neurocytomas at an uncommon location in the brain. The first, a 58-year-old man presenting with signs and symptoms of increased intracranial pressure, had a tumor located at the pineal region. The second, a 21-year-old woman with tumor in the aqueductal region had worsening migraine-like headaches and diplopia. Both patients had obstructive hydrocephalus treated by neuroendoscopic third ventriculostomy and biopsy of the tumors. No additional treatment was done. We conclude that neurocytomas should be considered in the differential diagnosis of tumors located in the pineal and aqueductal regions.

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