Tetanus Toxoid as an Antigen for Delayed Cutaneous Hypersensitivity

JAMA ◽  
1983 ◽  
Vol 249 (23) ◽  
pp. 3209 ◽  
Author(s):  
Jeffrey C. Delafuente
Keyword(s):  
Tetanus Toxoid ◽  
Cutaneous Hypersensitivity ◽  
Delayed Cutaneous Hypersensitivity

Delayed Cutaneous Hypersensitivity in Patients with Prostatic Adenocarcinoma

1975 ◽  
Vol 114 (1) ◽  
pp. 86-87 ◽  
Author(s):  
John C. Huus ◽  
Elroy D. Kursh ◽  
Peter Poor ◽  
Lester Persky
Keyword(s):  
Prostatic Adenocarcinoma ◽  
Cutaneous Hypersensitivity ◽  
Delayed Cutaneous Hypersensitivity

Delayed Cutaneous Hypersensitivity Reactions to Hirudin

2001 ◽  
Vol 125 (12) ◽  
pp. 1585-1587
Author(s):  
Kathleen J. Smith ◽  
Juan Rosario-Collazo ◽  
Henry Skelton
Keyword(s):  
Primary Treatment ◽  
Myocardial Infarctions ◽  
Hypersensitivity Reactions ◽  
Type Ii ◽  
Antithrombotic Agent ◽  
Heparin Induced Thrombocytopenia ◽  
Cutaneous Hypersensitivity ◽  
History Of ◽  
Delayed Hypersensitivity Reaction ◽  
Delayed Cutaneous Hypersensitivity

Abstract Hirudin is one of the new synthetic antithrombin agents, which is most commonly used in patients with type II heparin-induced thrombocytopenia and in patients with hypersensitivity reactions to unfractionated heparin as well as low-molecular-weight heparins. Hirudin is comparable to heparin as an antithrombotic agent and also has been studied as a primary treatment in patients who experienced acute myocardial infarctions. We describe a patient with a history of type II heparin-induced thrombocytopenia who was placed on intravenous hirudin therapy. After extravasation of the intravenous hirudin site, the patient developed a delayed hypersensitivity reaction that histologically showed an epithelioid granulomatous infiltrate. Although rare reports of hypersensitivity reactions to hirudin have been published, these reactions have not been well characterized and the histopathologic changes have not been described.

Mechanisms of Desensitization in Delayed Cutaneous Hypersensitivity

1992 ◽  
Vol 19 (11) ◽  
pp. 741-743 ◽  
Author(s):  
Ichiro Katayama ◽  
Takahiro Sato ◽  
Sayuri Yamazaki ◽  
Hiroo Yokozeki ◽  
Kiyoshi Nishioka
Keyword(s):  
Cutaneous Hypersensitivity ◽  
Delayed Cutaneous Hypersensitivity

scholarly journals THE RÔLE OF THE "WAX" OF THE TUBERCLE BACILLUS IN ESTABLISHING DELAYED HYPERSENSITIVITY

1948 ◽  
Vol 88 (4) ◽  
pp. 485-502 ◽  
Author(s):  
Sidney Raffel ◽  
John E. Forney
Keyword(s):  
Essential Element ◽  
Tubercle Bacillus ◽  
Adjuvant Activity ◽  
Long Duration ◽  
Simple Chemical ◽  
Cutaneous Hypersensitivity ◽  
Picryl Chloride ◽  
Delayed Cutaneous Hypersensitivity ◽  
Relationship Of ◽  
The Relationship

The purified wax fraction of the tubercle bacillus, which has been previously demonstrated as an essential element in causing delayed tuberculin hypersensitivity in response to the protein of the tubercle bacillus, is now found to have the same activity with regard to a simple chemical antigen, picryl chloride. One injection of this compound with wax intraperitoneally into guinea pigs results in a marked delayed cutaneous hypersensitivity, demonstrable by contact and intracutaneous test, and of long duration. The effect is not related to an adjuvant activity of the wax as defined by ordinary standards. The relationship of these observations to the occurrence of "heteroallergic" phenomena in tuberculosis is discussed. The possibility that the occurrence of spontaneous contact hypersensitivities may depend upon the presence of similarly active lipoidal components of the skin is commented upon.

Delayed Cutaneous Hypersensitivity in Leukaemic Patients to Autologous Blast Cells

1974 ◽  
Vol 27 (4) ◽  
pp. 627-634 ◽  
Author(s):  
Michael A. Baker ◽  
Robert N. Taub ◽  
Shelley M. Brown ◽  
Kmhatala Ramachandar
Keyword(s):  
Cutaneous Hypersensitivity ◽  
Blast Cells ◽  
Delayed Cutaneous Hypersensitivity
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