Nonsteroidal Anti-inflammatory Drugs, Muscle Relaxants, Opioids, and Other Treatments for Primary and Adjunctive Medical Management of Intervertebral Disc Herniation

2014 ◽  
pp. 186-193
Author(s):  
James M. Fingeroth ◽  
Franck Forterre ◽  
Núria Vizcaíno Revés ◽  
William B. Thomas
Keyword(s):  
Intervertebral Disc ◽  
Disc Herniation ◽  
Medical Management ◽  
Muscle Relaxants ◽  
Intervertebral Disc Herniation ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Comparative analysis of neurological recovery and adverse effects in chondrodystrophic dogs with thoracolumbar intervertebral disc herniation treated with methylprednisolone versus non-steroidal anti-inflammatory drugs

2021 ◽  
Author(s):  
William McCartney ◽  
Ciprian Andrei Ober ◽  
Maria Benito
Keyword(s):  
Treatment Group ◽  
Side Effects ◽  
Intervertebral Disc ◽  
Disc Herniation ◽  
Sodium Succinate ◽  
Neurological Recovery ◽  
Intervertebral Disc Herniation ◽  
Cord Injury ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Abstract Thoracolumbar intervertebral disc herniation is a common neurologic disease presented to the small-animal practitioner. The use of methylprednisolone sodium succinate (MPSS) as an adjunct to surgical decompression in cases of acute spinal cord injury following intervertebral disc extrusion is controversial. A prospective study was undertaken to compare the preoperative use of MPSS and non-steroidal anti-inflammatory drugs (NSAIDs) in 40 chondrodystrophic dogs presenting with similar signs and undergoing spinal decompressive surgery. Twenty dogs received MPSS and 20 had NSAIDs administered preoperatively. Dogs were administered with either MPSS intravenously 20 minutes before surgery (30 mg/kg) or NSAID (meloxicam 0.2mg/kg or carprofen 4 mg/kg) subcutaneously 20 minutes before surgery. Dogs were evaluated by neurologic examination of gait 24 hours postoperatively, at time of discharge and then at 8 weeks. The neurological recovery were similar in both groups, but the frequency of side effects such as vomiting (MPSS group: 90% versus NSAIDs group: 55%), and anorexia within the first three days (present in all 20 dogs pretreated with MPSS) was significantly different, with complications being more prevalent in the MPSS group. Side effects were significantly more evident with MPSS treatment group –including vomiting and anorexia during the first 3 days after surgery– than with NSAID treatment group, with a neurological recovery similar in both groups.

Comparative Analysis of Outcomes and Side Effects in Chondrodystrophic Dogs Treated With Preoperative Methylprednisolone Versus Non-steroidal Anti-inflammatory Drugs

2021 ◽  
Author(s):  
William McCartney ◽  
Ciprian Andrei Ober ◽  
Maria Benito
Keyword(s):  
Side Effects ◽  
Intervertebral Disc ◽  
Small Animal ◽  
Decompressive Surgery ◽  
Intervertebral Disc Herniation ◽  
Cord Injury ◽  
Inflammatory Drugs ◽  
Preliminary Study ◽  
Anti Inflammatory ◽  
Disc Extrusion

Abstract BackgroundThoracolumbar intervertebral disc herniation is likely the most common neurologic disease presented to the small-animal practitioner. The use of methylprednisolone (MPSS) as an adjunct to surgical decompression in cases of acute spinal cord injury following intervertebral disc extrusion is controversial. A prospective preliminary study was undertaken to compare the preoperative use of MPSS and non-steroidal anti-inflammatory drugs (NSAIDs) in 40 chondrodystrophic dogs presenting with similar signs and undergoing spinal decompressive surgery. ResultsTwenty dogs received MPSS and 20 had NSAIDs administered preoperatively. The outcomes were similar in both groups, but the frequency of side effects such as vomiting (MPSS group: 90% versus NSAIDs group: 55%), and anorexia within the first three days (present in all 20 dogs pretreated with MPSS) was significantly different, with complications being more prevalent in the MPSS group. This study details the preoperative use of MPSS in a cohort of similar dogs undergoing spinal decompressive surgery and compares the use of MPSS to NSAIDs. The use of MPSS is associated with higher adverse side effects than NSAIDs.ConclusionsOur results shows that MPSS use is associated with higher side effects than when using NSAIDs instead. Side effects are significantly more evident with MPSS –including vomiting and anorexia during the first 3 days after surgery– than with NSAID, with an outcome recovery similar in both groups.

Langzeitevaluation postoperativer Schmerzen nach thorakolumbaler Hemilaminektomie

2020 ◽  
Vol 48 (05) ◽  
pp. 377-377
Keyword(s):  
Postoperative Pain ◽  
Intervertebral Disc ◽  
Disc Herniation ◽  
Neuropathischer Schmerz ◽  
Intervertebral Disc Herniation ◽  
Pain Evaluation ◽  
Ca 50

Zidan N, Medland J, Olby NJ. Long-term postoperative pain evaluation in dogs with thoracolumbar intervertebral disc herniation after hemilaminectomy. J Vet Intern Med 2020. doi: 10.1111/jvim.15800. Beim Menschen ist chronischer neuropathischer Schmerz eine häufige Komplikation nach Rückenmarksinsulten, ca. 50–80 % der Patienten entwickeln eine derartige Dolenz. Für den Hund liegen diesbezüglich keine Studiendaten vor, vor allem aufgrund der herausfordernden Evaluierung insbesondere von neuropathischen Schmerzzuständen. Diese Studie prüfte die Verlässlichkeit einer Messung von spinalen mechanisch ausgelösten sensorischen Schwellenwerten (mechanical sensory threshholds, MSTs) und verglich die MSTs gesunder Hunde mit denen von Hunden nach operativer Hemilaminektomie aufgrund einer thorakolumbaren intervertebralen Diskherniation (IVDH).

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