Comparative analysis of neurological recovery and adverse effects in chondrodystrophic dogs with thoracolumbar intervertebral disc herniation treated with methylprednisolone versus non-steroidal anti-inflammatory drugs

2021 ◽  
Author(s):  
William McCartney ◽  
Ciprian Andrei Ober ◽  
Maria Benito
Keyword(s):  
Treatment Group ◽  
Side Effects ◽  
Intervertebral Disc ◽  
Disc Herniation ◽  
Sodium Succinate ◽  
Neurological Recovery ◽  
Intervertebral Disc Herniation ◽  
Cord Injury ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Abstract Thoracolumbar intervertebral disc herniation is a common neurologic disease presented to the small-animal practitioner. The use of methylprednisolone sodium succinate (MPSS) as an adjunct to surgical decompression in cases of acute spinal cord injury following intervertebral disc extrusion is controversial. A prospective study was undertaken to compare the preoperative use of MPSS and non-steroidal anti-inflammatory drugs (NSAIDs) in 40 chondrodystrophic dogs presenting with similar signs and undergoing spinal decompressive surgery. Twenty dogs received MPSS and 20 had NSAIDs administered preoperatively. Dogs were administered with either MPSS intravenously 20 minutes before surgery (30 mg/kg) or NSAID (meloxicam 0.2mg/kg or carprofen 4 mg/kg) subcutaneously 20 minutes before surgery. Dogs were evaluated by neurologic examination of gait 24 hours postoperatively, at time of discharge and then at 8 weeks. The neurological recovery were similar in both groups, but the frequency of side effects such as vomiting (MPSS group: 90% versus NSAIDs group: 55%), and anorexia within the first three days (present in all 20 dogs pretreated with MPSS) was significantly different, with complications being more prevalent in the MPSS group. Side effects were significantly more evident with MPSS treatment group –including vomiting and anorexia during the first 3 days after surgery– than with NSAID treatment group, with a neurological recovery similar in both groups.

Comparative Analysis of Outcomes and Side Effects in Chondrodystrophic Dogs Treated With Preoperative Methylprednisolone Versus Non-steroidal Anti-inflammatory Drugs

2021 ◽  
Author(s):  
William McCartney ◽  
Ciprian Andrei Ober ◽  
Maria Benito
Keyword(s):  
Side Effects ◽  
Intervertebral Disc ◽  
Small Animal ◽  
Decompressive Surgery ◽  
Intervertebral Disc Herniation ◽  
Cord Injury ◽  
Inflammatory Drugs ◽  
Preliminary Study ◽  
Anti Inflammatory ◽  
Disc Extrusion

Abstract BackgroundThoracolumbar intervertebral disc herniation is likely the most common neurologic disease presented to the small-animal practitioner. The use of methylprednisolone (MPSS) as an adjunct to surgical decompression in cases of acute spinal cord injury following intervertebral disc extrusion is controversial. A prospective preliminary study was undertaken to compare the preoperative use of MPSS and non-steroidal anti-inflammatory drugs (NSAIDs) in 40 chondrodystrophic dogs presenting with similar signs and undergoing spinal decompressive surgery. ResultsTwenty dogs received MPSS and 20 had NSAIDs administered preoperatively. The outcomes were similar in both groups, but the frequency of side effects such as vomiting (MPSS group: 90% versus NSAIDs group: 55%), and anorexia within the first three days (present in all 20 dogs pretreated with MPSS) was significantly different, with complications being more prevalent in the MPSS group. This study details the preoperative use of MPSS in a cohort of similar dogs undergoing spinal decompressive surgery and compares the use of MPSS to NSAIDs. The use of MPSS is associated with higher adverse side effects than NSAIDs.ConclusionsOur results shows that MPSS use is associated with higher side effects than when using NSAIDs instead. Side effects are significantly more evident with MPSS –including vomiting and anorexia during the first 3 days after surgery– than with NSAID, with an outcome recovery similar in both groups.

scholarly journals Emerging and Adjunctive Therapies for Spinal Cord Injury Following Acute Canine Intervertebral Disc Herniation

2020 ◽  
Vol 7 ◽  
Author(s):  
Melissa J. Lewis ◽  
Nicolas Granger ◽  
Nick D. Jeffery ◽  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Intervertebral Disc ◽  
Disc Herniation ◽  
Treatment Options ◽  
Surgical Techniques ◽  
Low Level Laser Therapy ◽  
Intervertebral Disc Herniation ◽  
Veterinary Clinic ◽  
Cord Injury

Some dogs do not make a full recovery following medical or surgical management of acute canine intervertebral disc herniation (IVDH), highlighting the limits of currently available treatment options. The multitude of difficulties in treating severe spinal cord injury are well-recognized, and they have spurred intense laboratory research, resulting in a broad range of strategies that might have value in treating spinal cord-injured dogs. These include interventions that aim to directly repair the spinal cord lesion, promote axonal sparing or regeneration, mitigate secondary injury through neuroprotective mechanisms, or facilitate functional compensation. Despite initial promise in experimental models, many of these techniques have failed or shown mild efficacy in clinical trials in humans and dogs, although high quality evidence is lacking for many of these interventions. However, the continued introduction of new options to the veterinary clinic remains important for expanding our understanding of the mechanisms of injury and repair and for development of novel and combined strategies for severely affected dogs. This review outlines adjunctive or emerging therapies that have been proposed as treatment options for dogs with acute IVDH, including discussion of local or lesion-based approaches as well as systemically applied treatments in both acute and subacute-to-chronic settings. These interventions include low-level laser therapy, electromagnetic fields or oscillating electrical fields, adjunctive surgical techniques (myelotomy or durotomy), systemically or locally-applied hypothermia, neuroprotective chemicals, physical rehabilitation, hyperbaric oxygen therapy, electroacupuncture, electrical stimulation of the spinal cord or specific peripheral nerves, nerve grafting strategies, 4-aminopyridine, chondroitinase ABC, and cell transplantation.

Intervertebral disc herniation in two coatis (Nasua nasua) and postoperative laminectomy membrane formation

2018 ◽  
Vol 46 (05) ◽  
pp. 330-336
Author(s):  
Michael Fehr ◽  
Jasmin Neßler ◽  
Alexandra Schütter ◽  
Peter Dziallas ◽  
Viktor Molnár ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Intervertebral Disc ◽  
Disc Herniation ◽  
The Other ◽  
Intervertebral Disc Herniation ◽  
Type I ◽  
Nasua Nasua ◽  
Post Surgery ◽  
Cord Injury ◽  
Laminectomy Membrane

SummaryMagnetic resonance imaging revealed spinal cord compression due to intervertebral disc herniation of Hansen type I and II in the thoracolumbar vertebral column in two middle-aged coatis (Nasua nasua) with chronic progressive paraparesis. Surgical treatment included hemilaminectomy and partial corpectomy in one and dorsal laminectomy in the other coati. Both coatis recovered well after surgery. One showed unremarkable gait 6 and 15 months post surgery, while the other one suffered from recurrence of paraparesis leading to euthanasia because of deterioration of neurological signs 20 months after the first surgery. Necropsy revealed formation of a laminectomy membrane compressing the spinal cord. Histopathological signs of spinal cord injury and findings of degenerative processes in the intervertebral disc were comparable to those described in dogs. In conclusion, this case report shows for the first time that surgical intervention seems to be a useful and safe treatment in chronic intervertebral disc herniation in coatis, but relapses are possible.

scholarly journals Combined Therapies of Modified Taiyi Miraculous Moxa Roll and Cupping for Patients with Lumbar Intervertebral Disc Herniation

2018 ◽  
Vol 2018 ◽  
pp. 1-6
Author(s):  
Chunyue Cai ◽  
Yuefeng Gong ◽  
Dayong Dong ◽  
Jinbiao Xue ◽  
Xiaoting Zheng ◽  
...  
Keyword(s):  
Treatment Group ◽  
Intervertebral Disc ◽  
Disc Herniation ◽  
Combined Treatment ◽  
Cupping Therapy ◽  
Control Group ◽  
Intervertebral Disc Herniation ◽  
Lumbar Intervertebral Disc ◽  
Lumbar Intervertebral Disc Herniation ◽  
And Control

Lumbar intervertebral disc herniation is a kind of syndrome caused by stimulation or pressure of nerve root and cauda equina due to intervertebral disc disorder, fibrous ring rupture, and pulpiform nucleus protrusion. Application of traditional Chinese medicine (TCM) including acupuncture therapy and cupping therapy is unique and effective treatment for lumbar intervertebral disc herniation in China. Hence, we try to investigate the combined clinical efficacy of modified Taiyi miraculous moxa roll and cupping therapy on patients with lumbar intervertebral disc herniation. Seventy patients were randomly assigned into combined treatment group (n=35) and control group (n=35). The treatment group received combined therapy of modified Taiyi miraculous moxa roll and cupping therapy, while control group received acupuncture therapy alone. Diagnostic criteria of TCM syndrome, Japanese Orthopedic Association (JOA) score, and simplified McGill pain questionnaire (MPQ) were used to evaluate the therapy. 11 and 13 out of 35 subjects in the combined treatment group had improvement > 75% and between 50% and 75%, respectively. The corresponding number was 2 and 22 of 35 subjects in the acupuncture group. There was significant difference in the clinical efficacy between the treatment group and control group (P=0.036). The scores of JOA and MPQ detected in the patients of the two groups (P<0.05) also showed statistically significant differences. Moreover, no serious adverse events occurred in the patients, who received cupping therapy or acupuncture. The combined or alone therapies can effectively improve the treatment efficacy in the patients with lumbar intervertebral disc herniation, while the combined therapies show more comparative effectiveness. Furthermore, the combined therapies are potentially safe and cost-effective and also benefit the improvement of short-term pain. Therefore, the combined therapies of the two ancient TCM deserve further clinical applications.

Comparison of Gait Assessment Scales in Dogs with Spinal Cord Injury from Intervertebral Disc Herniation

2020 ◽  
Vol 37 (18) ◽  
pp. 1991-1998 ◽  
Author(s):  
Natasha Olby ◽  
Emily Griffith ◽  
Jon Levine ◽  
Ronaldo da Costa ◽  
Joseph Fenn ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Intervertebral Disc ◽  
Disc Herniation ◽  
Intervertebral Disc Herniation ◽  
Gait Assessment ◽  
Cord Injury ◽  
Assessment Scales
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