In the recent years, poorly evaluated gynecological surgeries and urogynecological mesh implantations have been affecting millions of women in the US and across the globe. These failed surgeries could be mainly attributed to the nonavailability of vaginal tissues (due to ethical and biosafety issues), which does not allow any experimental testing of operation and mesh implantation techniques before an actual surgery. A surrogate which behaves biomechanically like the human vaginal tissue would be indispensable for simulating surgical suture of vaginal tissues in prolapse surgery, hysterectomy or surgery during traumatic child births (such as Cesarean). Also, vaginal tissue surrogates simulating the various prolapse conditions (such as vaginal tissue stiffening) would be very useful to evaluate tissue modifications due to prolapse, and also mesh and vaginal tissue interactions. In the current work, a low cost four-part silicone-based material was developed, which precisely simulates the linear and nonlinear mechanical behavior of the normal human vaginal tissue. Additionally, a range of four-part silicone-based novel materials were developed which precisely mimics the mechanical behavior of stiffened vaginal tissues at different degrees of prolapse. The linear and nonlinear mechanical behavior of all such novel materials were characterized using elastic and hyperelastic formulations. Such precisely characterized normal and prolapsed vaginal tissue surrogates have not been developed anywhere to date as per the best of our knowledge and would be clinically helpful for gynecological surgical planning in the future.
Nonlinear mechanical response of DNA due to anisotropic bending elasticity
