Combined application of pharamcokinetic DCE‐MRI and IVIM‐DWI could improve detection efficiency in early diagnosis of ductal carcinoma in situ

Breast carcinoma is a heterogeneous group of tumors with a wide spectrum of clinical presentations, lesion characterization and diagnostic evaluation. Ductal carcinoma in situ accounts for 15%-20% of breast carcinomas detected in screened populations. Ductal carcinoma in situ has a variable appearance on mammography. The use of mammography has become as a very helpful tool for the early detection of larger number of patients with ductal carcinoma in situ and, thus, offering timely surgery and the need for the appropriate radiation treatment to patients. This study was undertaken as a hospital-based retrospective study to evaluate the varied spectrum of mammographic findings in 57 women with histopathological diagnosis of ductal carcinoma in situ. The spectrum of mammographic findings of ductal carcinoma in situ was found to vary widely. A thorough and vigilant inspection of a mammogram is necessary for all the patients to avoid the possibility of missing early diagnosis of this entity, since the findings are very subtle. Most cases show microcalcifications on mammograms and their early detection can help in early diagnosis, thereby offering conservative surgical approach to a patient. Microcalcifications can be present isolated or in association with a mass. These are mostly clustered in distribution followed by regional, segmental and ductal pattern of distribution. The morphology of microcalcifications is mostly amorphous, followed by pleiomorphic and fine heterogenous types. Hence, the mammogram must be interpreted with strict vigilance and proper attention to all aspects for early and correct diagnosis of ductal carcinoma in situ to help in proper guidance of its treatment.

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Label-Free Identification of Early Stages of Breast Ductal Carcinoma via Multiphoton Microscopy

Scanning ◽

10.1155/2020/9670514 ◽

2020 ◽

Vol 2020 ◽

pp. 1-8 ◽

Cited By ~ 1

Author(s):

Zhong Chen ◽

Wenhui Guo ◽

Deyong Kang ◽

Shu Wang ◽

Liqin Zheng ◽

...

Keyword(s):

Breast Cancer ◽

Early Diagnosis ◽

Ductal Carcinoma In Situ ◽

Carcinoma In Situ ◽

Ductal Carcinoma ◽

Multiphoton Microscopy ◽

Label Free ◽

Early Stages ◽

Cytological Features

Breast cancer can be cured by early diagnosis. Appropriate and effective clinical treatment benefits from accurate pathological diagnosis. However, due to the lack of effective screening and diagnostic imaging methods, early stages of breast cancer often progress to malignant breast cancer. In this study, multiphoton microscopy (MPM) via two-photon excited fluorescence combined with second-harmonic generation was used for identifying the early stages of breast ductal carcinoma. The results showed differences in both cytological features and collagen distribution among normal breast tissue, atypical ductal hyperplasia, low-grade ductal carcinoma in situ, and high-grade ductal carcinoma in situ with microinvasion. Furthermore, three features extracted from the MPM images were used to describe differences in cytological features, collagen density, and basement membrane circumference in the early stages of breast ductal carcinoma. They revealed that MPM has the ability to identify early stages of breast ductal carcinoma label-free, which would contribute to the early diagnosis and treatment of breast cancer. This study may provide the groundwork for the further application of MPM in the clinic.

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